2-Aminopurine

Suppliers

Names

[ CAS No. ]:
452-06-2

[ Name ]:
2-Aminopurine

[Synonym ]:
2-Aminoperin
iso-Adenine
2-Aminopurine
3H-Purin-2-amine
MFCD07357244
7H-Purin-2-amine
9H-Purin-2-amine
2-amino purine
EINECS 207-197-4
9H-purin-2-ylamine
Purine, 2-amino-
2-amino-6-purine
1H-Purin-2-amine
4-aminopurine
2-amino-purin
SQ 22,451

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
328.2±25.0 °C at 760 mmHg

[ Melting Point ]:
280-282 °C(lit.)

[ Molecular Formula ]:
C5H5N5

[ Molecular Weight ]:
135.127

[ Flash Point ]:
152.3±23.2 °C

[ Exact Mass ]:
135.054489

[ PSA ]:
80.48000

[ LogP ]:
-1.33

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.954

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO7475000
CHEMICAL NAME :
Purine, 2-amino-
CAS REGISTRY NUMBER :
452-06-2
LAST UPDATED :
199612
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C5-H5-N5
MOLECULAR WEIGHT :
135.15
WISWESSER LINE NOTATION :
T56 BN DM FN HNJ GZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
723 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Specific locus test

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Embryo
DOSE/DURATION :
100 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 78,5685,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UO7475000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Amino-6-chloropurine
  • Amipurimycin
  • 2-Methylthiopurine
  • 6-Thioguanine
  • (Z)-Methanimidic acid
  • 2,4,5-Pyrimidinetriamine
  • [(2S,5R)-5-(2-aminopurin-9-yl)oxolan-2-yl]methanol
  • 9H-Purin-2-amine,9-(2-deoxy-b-D-erythro-pentofuranosyl)-

DownStream

  • [(2S,5R)-5-(2-aminopurin-9-yl)oxolan-2-yl]methanol
  • 2-amino-9-(β-D-ribofuranosyl)purine
  • Famciclovir
  • 9H-Purin-2-amine,9-(2-deoxy-b-D-erythro-pentofuranosyl)-
  • 2-[(2-aminopurin-7-yl)methoxy]ethanol
  • Desciclovir

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Site-specific fluorescence dynamics in an RNA 'thermometer' reveals the role of ribosome binding in its temperature-sensitive switch function.

Nucleic Acids Res. 43(1) , 493-503, (2015)

RNA thermometers control the translation of several heat shock and virulence genes by their temperature-sensitive structural transitions. Changes in the structure and dynamics of MiniROSE RNA, which r...

Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming.

Mol. Cancer 10 , 20, (2011)

As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses.Here we characterise the effects of conditioned m...

Ligand-induced evolution of intrinsic fluorescence and catalytic activity from cobalt ferrite nanoparticles.

ChemPhysChem 16 , 1627-34, (2015)

To develop CoFe(2)O(4) as magneto-fluorescent nanoparticles (NPs) for biomedical applications, it would be advantageous to identify any intrinsic fluorescence of this important magnetic material by si...


More Articles

Related Compounds

  • 2-Aminopurine
  • 2-Aminopurine
  • 2-Aminopurine
  • 6-I-2-aminopurine
  • 2-Aminopurine nitrate
  • 3-Deaza-2-aminopurine
  • 3-Fluoro-2-methoxy-5-methylpyridine
  • 2-Fluorothiophene-3-carbaldehyde
  • 2-(4-Diethylaminophenyl)ethylamine dihydrochloride
  • 5-(2-Bromoprop-2-enyl)-5-butan-2-yl-1-methyl-1,3-diazinane-2,4,6-trione
  • 1,1a(2),2,2a(2),5a(2),6a(2),7a(2),7a(2)a-Octahydro-N-[(4-methylphenyl)methyl]-2-oxospiro[3H-indole-3,3a(2)-[3H]pyrrolizine]-2a(2)-carboxamide
  • N-(2-(Benzyloxy)phenyl)methanesulfonamide
  • 1-(4-Methyl-3-nitropyridin-2-yl)piperazine
  • 6-Methyl-2-(piperazin-1-yl)nicotinonitrile
  • 4-Bromo-1,2-diethylbenzene
  • 2-(4-Phenylbutoxy)ethanol