2-Bromo-4-fluoro-1-methoxybenzene

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Names

[ CAS No. ]:
452-08-4

[ Name ]:
2-Bromo-4-fluoro-1-methoxybenzene

[Synonym ]:
1-Bromo-3-fluoro-6-methoxybenzene
2-BroMo-4-fluoroanisole
2-Bromo-4-fluorophenyl methyl ether
Benzene, 2-bromo-4-fluoro-1-methoxy-
2-Bromo-4-fluoro-1-methoxybenzene
MFCD00012014

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
273.6±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H6BrFO

[ Molecular Weight ]:
205.02

[ Flash Point ]:
98.3±0.0 °C

[ Exact Mass ]:
203.958603

[ PSA ]:
9.23000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.519

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909309090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromo-4-fluorophenol
  • methyl iodide
  • 4-Fluorobenzyl alcohol
  • 5-Fluoro-o-anisidine
  • 4-Fluoro-1-methoxy-2-nitrobenzene

DownStream

  • 2-Bromo-4-fluorophenol
  • 5-Fluoro-2-methoxybenzyl alcohol
  • 4-(5-fluoro-2-methoxybenzyl)morpholine
  • 1-Bromo-5-fluoro-2-methoxy-3-nitrobenzene
  • 5-Fluoro-2-methoxybenzonitrile
  • 5-fluoro-2-methoxyphenylmagnesium bromide
  • 5-Fluoro-2-methoxyphenol
  • 5-Fluoro-2-methoxybenzaldehyde

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.

J. Org. Chem. 78(12) , 5955-63, (2013)

An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a ratio...


More Articles

Related Compounds

  • 2-Bromo-4-Fluoro-1-(2-Nitrovinyl)Benzene
  • 2-Bromo-4-fluoro-1-(isopropoxymethyl)benzene
  • 2-bromo-4-fluoro-1-(2,2,2-trifluoroethyl)benzene
  • 2-bromo-4-fluoro-1,1'-biphenyl
  • 2-Bromo-4-fluoro-1-((2-fluorobenzyl)oxy)benzene
  • 2-bromo-4-fluoro-1-(2-nitroethyl)benzene
  • 1,1,1-Trifluoro-3-(4-fluoro-3-nitrophenyl)propan-2-amine
  • 1-(3,4-Dichlorophenyl)-3-(2-methylpropanoyl)piperidin-2-one
  • 3-[1-(4-Methoxyphenyl)-2-oxopiperidin-3-yl]-3-oxopropanenitrile
  • 1-(4-Methoxyphenyl)-3-(2-methylpropanoyl)piperidin-2-one
  • 3-[1-(3-Chlorophenyl)-2-oxopiperidin-3-yl]-3-oxopropanenitrile
  • 3-(2-Bromo-2-methylpropanoyl)-1-(3-chlorophenyl)piperidin-2-one
  • 3-[1-(3-Chlorophenyl)-2-oxopiperidin-3-yl]-2-methyl-3-oxopropanenitrile
  • 3-[1-(3-Fluorophenyl)-2-oxopiperidin-3-yl]-3-oxopropanenitrile
  • 1-(3-Fluorophenyl)-3-(2-methylpropanoyl)piperidin-2-one
  • 3-(2-Bromo-2-methylpropanoyl)-1-(3-fluorophenyl)piperidin-2-one
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