2-Bromo-4-fluoro-1-methoxybenzene

2-Bromo-4-fluoro-1-methoxybenzene Structure
2-Bromo-4-fluoro-1-methoxybenzene structure
Common Name 2-Bromo-4-fluoro-1-methoxybenzene
CAS Number 452-08-4 Molecular Weight 205.02
Density 1.5±0.1 g/cm3 Boiling Point 273.6±0.0 °C at 760 mmHg
Molecular Formula C7H6BrFO Melting Point N/A
MSDS Chinese USA Flash Point 98.3±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.

J. Org. Chem. 78(12) , 5955-63, (2013)

An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled tele...