DL-Homocysteine

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Names

[ CAS No. ]:
454-29-5

[ Name ]:
DL-Homocysteine

[Synonym ]:
DL-HoMocysteine
DL-2-amino-4-mercapto-Butyric acid
D-L-homocysteine
usafb-12
Butyric acid, 2-amino-4-mercapto-
DL-2-Amino-4-mercaptobutyric acid
Butyric acid, 2-amino-4-mercapto-, DL-
2-Amino-4-mercaptobutyric acid
D,L-Homocysteine
2-Amino-4-mercaptobutanoic acid
HOMOCYSTEINE,DL
2-AMINO-4-MERCAPTOBUYRIC ACID
1-carboxy-3-mercaptopropylamine
Butanoic acid, 2-amino-4-mercapto-
2-amino-4-mercapto-DL-Butyric acid
2-amino-4-sulfanylbutanoic acid
Homocysteine (VAN)
TOTALHOMOCYSTEINE
H-DL-Hcys-OH
2-Amino-4-Mercapto-Butyric Acid
EINECS 207-222-9
homocystine
(±)-Homocysteine
2-amino-4-mercapto-Butanoic acid
UNII:S7IJP4A89K
MFCD00004898
Homocysteine
2-thioethylglycine
Butyric acid, 2-amino-4-mercapto-, DL- (9CI)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
299.7±35.0 °C at 760 mmHg

[ Melting Point ]:
232-233 °C(lit.)

[ Molecular Formula ]:
C4H9NO2S

[ Molecular Weight ]:
135.185

[ Flash Point ]:
135.0±25.9 °C

[ Exact Mass ]:
135.035400

[ PSA ]:
102.12000

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MT0175000
CHEMICAL NAME :
DL-Homocysteine
CAS REGISTRY NUMBER :
454-29-5
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H9-N-O2-S
MOLECULAR WEIGHT :
135.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
125 mg/L
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
C

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MT0175000

[ HS Code ]:
2930909090

Synthetic Route

Precursor & DownStream

Precursor

  • 2(3H)-Furanone,3-aminodihydro-(8CI,9CI)
  • 4,4'-Dithiobis[2-aminobutyric Acid]
  • s-benzyl-dl-homocysteine
  • 3-Aminodihydro-2(3H)-thiophenone hydrochloride
  • DL-Methionine

DownStream

  • D-methionine
  • 3-sulfanylpropanal
  • L-Methionine
  • SAH
  • DL-Methionine
  • 3-carboxypropyl disulfide
  • 2-amino-4-(methyldisulfanyl)butanoic acid
  • CBHcy
  • 5-(delta-carboxybutyl)homocysteine

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2.

Bone 77 , 135-41, (2015)

Elevated plasma homocysteine (Hcy) level is associated with the risk of osteoporotic fracture. While Hcy increases oxidative stress, AMP-activated protein kinase (AMPK) activation ameliorates it. This...

Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients.

Life Sci. 132 , 61-7, (2015)

One of the main features of sulfurous water (SW) is the presence of hydrogen sulfide (H2S), which confers its antioxidant activity. Since oxidative stress plays an important role in Alzheimer's diseas...

Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...


More Articles


Related Compounds

  • DL-Homocysteine
  • DL-Homocysteinethiol
  • S-Ethyl-DL-homocysteine
  • S-Vinyl-DL-homocysteine
  • S-Sulfo-DL-homocysteine
  • S-Ethyl-DL-homocysteine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • (4S)-2-(2,6-dichlorophenyl)-3-(2,2,2-trifluoroacetyl)-1,3-thiazolidine-4-carboxylic acid
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide