4-Fluorophenylacetyl chloride

Names

[ CAS No. ]:
459-04-1

[ Name ]:
4-Fluorophenylacetyl chloride

[Synonym ]:
MFCD00674181
2-(4-fluorophenyl)acetyl chloride

Chemical & Physical Properties

[ Density]:
1.259

[ Boiling Point ]:
60 °C (8 mmHg)

[ Melting Point ]:
47-48

[ Molecular Formula ]:
C₈H₆ClFO

[ Molecular Weight ]:
172.58400

[ Flash Point ]:
107 °C

[ Exact Mass ]:
172.00900

[ PSA ]:
17.07000

[ LogP ]:
2.13360

[ Vapour Pressure ]:
0.0884mmHg at 25°C

[ Index of Refraction ]:
1.511-1.513

[ Storage condition ]:
Store at RT.

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xi: Irritant;C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S45-S36/37/39-S26-S27

[ RIDADR ]:
3265

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Fluorophenylacetic acid
4-Fluorophenyl acetate
Oxalyl chloride
4-Fluorotoluene
AM0210000 [RTECS]
4-Fluorobenzyl bromide

DownStream

2-(4-Fluorophenyl)-1-phenylethanone
1,2-Bis(4-fluorophenyl)ethanone
2-Fluoro-6-methylnaphthalene
Methyl 2-(4-fluorophenyl)acetate
4-Fluorophenylacetic acid
4-Fluorophenylacetone
DIETHYL 4-FLUOROPHENYL MALONATE
1-amino-3-(4-fluorophenyl)propane-2-one hydrochloric acid salt
2-(4-Fluorophenyl)propanoic Acid

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives.

Chem. Pharm. Bull. 44 , 765, (1996)

In order to find new antiasthmatic and antithrombotic agents, various [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives were synthesized. Evaluation of these compounds ...

Drug Des. Discovery 11 , 115, (1994)

Drug Des. Discovery 9 , 155, (1992)

2,5-bis-(Chloromethyl)-1-methoxy-4-(2-ethylhexyloxy)benzene
(S)-(-)-α-cyano-α-fluorophenylacetyl chloride
α-fluorophenylacetic acid chloride
(R)-(-)-α-fluoro phenyl acetyl chloride
N-TFA-Asp(Cl)-OMe
4-Isopropylbenzenesulfonyl chloride
N'-(4,5-dimethyl-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
(Z)-N-((1,2-dimethyl-1H-indol-5-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
1,1-Diethyl-3-(1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl)urea
N'-(4-methylbenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide
1-(1-(4-Methylpiperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)-3-phenethylthiourea
4-bromo-N-[3-(9-fluorenylideneamino)oxy-2-hydroxypropyl]-N-methylbenzenesulfonamide
N1-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-((tetrahydrofuran-2-yl)methyl)oxalamide
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-(pyridin-4-ylmethyl)oxalamide
N1-(2-(furan-2-yl)-2-(4-phenylpiperazin-1-yl)ethyl)-N2-((tetrahydrofuran-2-yl)methyl)oxalamide
Benzyl (2-(4-(4-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)carbamate