4-Fluoro-N-methylaniline

Names

[ CAS No. ]:
459-59-6

[ Name ]:
4-Fluoro-N-methylaniline

[Synonym ]:
EINECS 207-294-1
4-fluoro-n-methylaniline
MFCD00017942

Chemical & Physical Properties

[ Density]:
1.1057

[ Boiling Point ]:
79-80ºC(10 torr)

[ Melting Point ]:
79-80°C

[ Molecular Formula ]:
C₇H₈FN

[ Molecular Weight ]:
125.14400

[ Flash Point ]:
75ºC

[ Exact Mass ]:
125.06400

[ PSA ]:
12.03000

[ LogP ]:
1.94040

[ Vapour Pressure ]:
0.853mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.5320(lit.)

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
UN 2810 6

[ WGK Germany ]:
2

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.

Drug Metab. Dispos. 21(2) , 218-30, (1993)

In vivo and in vitro biotransformation of secondary aromatic amines was investigated using 4-fluoro-N-methylaniline as the model compound. Attention was focused on the role of cytochromes P-450 and th...

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

Chem. Res. Toxicol. 23(5) , 861-3, (2010)

Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. FMO1 catalyzed a carbon oxidation reac...

2-bromo-4-fluoro-N-methylaniline
3-Chloro-4-fluoro-N-methylaniline
2-chloro-4-fluoro-N-methylaniline
2-methyl-4-fluoro-N-methylaniline
N-dimethylboranyl-4-fluoro-N-methylaniline
2-(2-chloro-4-nitrophenyl)sulfanyl-4-fluoro-N-methylaniline
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
3-Diazo-7-(diethylamino)-2H-1-benzopyran-2,4(3H)-dione