4-Fluoro-N-methylaniline
4-Fluoro-N-methylaniline structure
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Common Name | 4-Fluoro-N-methylaniline | ||
|---|---|---|---|---|
| CAS Number | 459-59-6 | Molecular Weight | 125.14400 | |
| Density | 1.1057 | Boiling Point | 79-80ºC(10 torr) | |
| Molecular Formula | C7H8FN | Melting Point | 79-80°C | |
| MSDS | Chinese USA | Flash Point | 75ºC | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.
Drug Metab. Dispos. 21(2) , 218-30, (1993) In vivo and in vitro biotransformation of secondary aromatic amines was investigated using 4-fluoro-N-methylaniline as the model compound. Attention was focused on the role of cytochromes P-450 and the flavin-containing monooxygenase in formation of the vario... |
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Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.
Chem. Res. Toxicol. 23(5) , 861-3, (2010) Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. FMO1 catalyzed a carbon oxidation reaction coupled with defluorination that led to the formation ... |
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