1-acetylaziridine

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Names

[ CAS No. ]:
460-07-1

[ Name ]:
1-acetylaziridine

[Synonym ]:
1-Acetylaziridine
N-acetyl aziridine
Acetylethylenimide
N-Acetylethyleneimine
AZIRIDINE,1-ACETYL
1-Acetyl-aziridin
Acetylethylenimine
EINECS 207-301-8
N-Acetylethylenimine
Acetylethyleneimine

Chemical & Physical Properties

[ Density]:
1.126g/cm3

[ Boiling Point ]:
174.2ºC at 760mmHg

[ Molecular Formula ]:
C4H7NO

[ Molecular Weight ]:
85.10450

[ Flash Point ]:
76.2ºC

[ Exact Mass ]:
85.05280

[ PSA ]:
20.08000

[ Vapour Pressure ]:
1.22mmHg at 25°C

[ Index of Refraction ]:
1.494

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM6300000
CHEMICAL NAME :
Aziridine, 1-acetyl-
CAS REGISTRY NUMBER :
460-07-1
BEILSTEIN REFERENCE NO. :
0105879
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H7-N-O
MOLECULAR WEIGHT :
85.12
WISWESSER LINE NOTATION :
T3NTJ AV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
78 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg/33W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg/16W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Aziridine
  • Acetyl chloride
  • ketene

DownStream

  • Acetamide,N-(2-mercaptoethyl)-
  • N-(2-methoxyethyl)acetamide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-acetylaziridine-2-carboxylic acid
  • methyl 1-acetylaziridine-2-carboxylate
  • (S)-methyl 1-acetylaziridine-2-carboxylate
  • 1-[2-(2-methoxybenzoyl)pyrrol-1-yl]propan-2-yl-dimethylazanium,chloride
  • 1-methyl-3-[3-[[methyl-[(4-nitrophenyl)methyl]carbamoyl]amino]phenyl]-1-[(4-nitrophenyl)methyl]urea
  • 1-(2-methoxyphenyl)-4-(2-phenylethyl)piperazine
  • 6-Hydroxy-1-methylazepan-2-one
  • (2S,4S)-4-(Cyclobutylmethyl)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
  • (S)-Cyclopentyl(dimethylphosphoryl)methanamine
  • 3-(2-Bromo-5-chlorosulfonyl-4-methoxyphenyl)propanoic acid
  • 3-({[(benzyloxy)carbonyl]amino}methyl)-5H,6H,7H-pyrrolo[2,1-c][1,2,4]triazole-6-carboxylic acid
  • 3-[(3,3-Difluorocyclobutyl)methoxy]pyridin-2-amine
  • 1-(2,5-Dimethylpyrazol-3-yl)pyrrolidin-3-amine
  • 4-(3,4-Dihydro-2H-1,4-benzoxazin-6-yl)benzonitrile
  • 1-(tert-Butoxycarbonyl)-1-azaspiro[3.3]heptane-2-carboxylic acid
  • (4,5-Dihydro-1,2-oxazol-3-yl)methanesulfonamide
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