1-acetylaziridine

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Names

[ CAS No. ]:
460-07-1

[ Name ]:
1-acetylaziridine

[Synonym ]:
1-Acetylaziridine
N-acetyl aziridine
Acetylethylenimide
N-Acetylethyleneimine
AZIRIDINE,1-ACETYL
1-Acetyl-aziridin
Acetylethylenimine
EINECS 207-301-8
N-Acetylethylenimine
Acetylethyleneimine

Chemical & Physical Properties

[ Density]:
1.126g/cm3

[ Boiling Point ]:
174.2ºC at 760mmHg

[ Molecular Formula ]:
C₄H₇NO

[ Molecular Weight ]:
85.10450

[ Flash Point ]:
76.2ºC

[ Exact Mass ]:
85.05280

[ PSA ]:
20.08000

[ Vapour Pressure ]:
1.22mmHg at 25°C

[ Index of Refraction ]:
1.494

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM6300000

CHEMICAL NAME :: Aziridine, 1-acetyl-

CAS REGISTRY NUMBER :: 460-07-1

BEILSTEIN REFERENCE NO. :: 0105879

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H7-N-O

MOLECULAR WEIGHT :: 85.12

WISWESSER LINE NOTATION :: T3NTJ AV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 78 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg/33W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg/16W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,306,1954

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Aziridine
Acetyl chloride
ketene

DownStream

Acetamide,N-(2-mercaptoethyl)-
N-(2-methoxyethyl)acetamide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

1-acetylaziridine-2-carboxylic acid
methyl 1-acetylaziridine-2-carboxylate
(S)-methyl 1-acetylaziridine-2-carboxylate
1-[2-(2-methoxybenzoyl)pyrrol-1-yl]propan-2-yl-dimethylazanium,chloride
1-methyl-3-[3-[[methyl-[(4-nitrophenyl)methyl]carbamoyl]amino]phenyl]-1-[(4-nitrophenyl)methyl]urea
1-(2-methoxyphenyl)-4-(2-phenylethyl)piperazine
2-Chloro-4-morpholin-4-yl-7-phenyl-thieno[3,2-d]pyrimidine
N-(2-(3-(thiophen-3-yl)-1H-pyrazol-1-yl)ethyl)tetrahydrofuran-3-carboxamide
2-(2-fluorophenoxy)-N-(2-(3-(thiophen-3-yl)-1H-pyrazol-1-yl)ethyl)acetamide
(1S)-1-Cyclopropylprop-2-yn-1-ol
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