chlorоphentermine

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Names

[ CAS No. ]:
461-78-9

[ Name ]:
chlorоphentermine

[Synonym ]:
Lucofen SA
Chlorphenterminum [INN-Latin]
Effox
Chlorphenterminum
Clorfentermina [INN-Spanish]
3-(4-chlorophenyl)-2-methyl-2-propylamin
Clorfentermina
Teramine
chlorophentermine
chlorphentermine
Desopimon
1,1-dimethyl-2-(4-chlorophenyl)ethylamine

Chemical & Physical Properties

[ Density]:
1.074g/cm3

[ Boiling Point ]:
255.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₄ClN

[ Molecular Weight ]:
183.67800

[ Flash Point ]:
127ºC

[ Exact Mass ]:
183.08100

[ PSA ]:
26.02000

[ LogP ]:
3.32010

[ Vapour Pressure ]:
0.016mmHg at 25°C

[ Index of Refraction ]:
1.537

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH1050000

CHEMICAL NAME :: Phenethylamine, p-chloro-alpha,alpha-dimethyl-

CAS REGISTRY NUMBER :: 461-78-9

BEILSTEIN REFERENCE NO. :: 1099928

LAST UPDATED :: 199709

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C10-H14-Cl-N

MOLECULAR WEIGHT :: 183.70

WISWESSER LINE NOTATION :: ZX1&1&1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5357 ug/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic Vascular - BP elevation not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 mg/kg/6W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/15W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/6W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg/13W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 480 mg/kg

SEX/DURATION :: female 10-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/5D (Continuous)

REFERENCE :: 40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year: -,459,1978 *** REVIEWS *** TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976

Safety Information

[ HS Code ]:
29222900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(4-Chlorophenyl)-2-methyl-2-propanol
N-[1-(4-chlorophenyl)-2-methyl-propan-2-yl]formamide
4-Chlorobenzyl chloride
Methyl 4-chlorophenylacetate

DownStream

N-(2-(4-Chlorophenyl)-1,1-dimethylethyl)acetamide
1-(2-acetylphenothiazin-10-yl)-2-[[1-(4-chlorophenyl)-2-methylpropan-2-yl]amino]ethanone
α,α-Dimethylcyclohexaneethanamine

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[2-methyl-5-(propan-2-yl)phenoxy]propanoate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1-[4-(propan-2-yl)phenyl]cyclobutane-1-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(4-chlorobenzoyl)-1,3-thiazolidine-4-carboxylate
4-Amino-3-(4-bromofuran-2-yl)butanoic acid
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 5-cyano-2-methyl-1H-pyrrole-3-carboxylate
rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (1R,2R)-2-(3,4-dimethylphenyl)cyclopropane-1-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)propanoate
1-Fluoro-3-(2-isocyanatoethyl)-2-methoxybenzene
Tert-butyl 2-{[hydroxy(methyl)amino]methyl}-5,5-dimethylpiperidine-1-carboxylate

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