Glycyrrhetinic acid

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Names

[ CAS No. ]:
471-53-4

[ Name ]:
Glycyrrhetinic acid

[Synonym ]:
MFCD00003706
(3β)-3-Hydroxy-11-oxoolean-12-en-30-oic acid
Glycyrrhetinic acid
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-2-picenecarboxylic acid
18-beta-Glycyrrhetinic acid
Arthrodont
EINECS 207-444-6
18-β-Glycyrrhetinic Acid
glycyrrhetin
GM 1658
Uralenic acid
3β-Hydroxy-11-oxoolean-12-en-30-oic acid
18b-Glycyrrhetic acid
Biosone
Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-
18β-Glycyrrhetinic acid
STX 352
Glycyrrhetic Acid
PO 12
Olean-12-en-30-oic acid, 3-hydroxy-11-oxo-, (3β)-
3b-Hydroxy-11-oxoolean-12-en-30-oic Acid
18b-Glycyrrhetinic Acid
Glycyrrhetinate
(3b,20b)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid
ENOLOXONE
enoxolone

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
588.3±50.0 °C at 760 mmHg

[ Melting Point ]:
292 - 295ºC

[ Molecular Formula ]:
C30H46O4

[ Molecular Weight ]:
470.684

[ Flash Point ]:
323.7±26.6 °C

[ Exact Mass ]:
470.339600

[ PSA ]:
74.60000

[ LogP ]:
6.57

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK0180000
CHEMICAL NAME :
Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-
CAS REGISTRY NUMBER :
471-53-4
BEILSTEIN REFERENCE NO. :
2229654
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C30-H46-O4
MOLECULAR WEIGHT :
470.76
WISWESSER LINE NOTATION :
L F6 E6 B666 CV DUTJ A1 HVQ H1 K1 N1 O1 S1 S1 TQ -ALPHA

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
308 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,319,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02067

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RK0180000

[ HS Code ]:
2938909030

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 18α-Glycylrrhizin
  • 6',6''-dibenzyl-18β-glycyrrhizin
  • Glycyrrhizic acid
  • Glycyrrhizic acid ammonium salt
  • apioglycyrrhizin
  • Glycyrrhetic acid 3-O-mono-beta-D-glucuronide
  • araboglycyrrhizin
  • Methanol

DownStream

  • Glycyrrhetic acid 3-O-mono-beta-D-glucuronide
  • olean-11,13(18)-diene-3,30-diol dihemiphthalate, disodium salt
  • 18-olean-9(11),12-diene-3,30-diol dihemiphthalate
  • Stearyl glycyrrhetinate
  • Glycyrrhetinic acid
  • Naphthalene, 1,2,7-trimethyl-

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • Glycyrrhetinic acid
  • glycyrrhetinic acid
  • 3-oxoglycyrrhetinic acid
  • Acetylglycyrrhetinic acid
  • glycyrrhetinic acid glycoside
  • glycyrrhetinic acid glycoside
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