Hematein

Names

[ CAS No. ]:
475-25-2

[ Name ]:
Hematein

[Synonym ]:
hydroxybrazilein
Haematein
EINECS 207-492-8

Chemical & Physical Properties

[ Density]:
1.77g/cm3

[ Boiling Point ]:
753.1ºC at 760mmHg

[ Melting Point ]:
180ºC

[ Molecular Formula ]:
C₁₆H₁₂O₆

[ Molecular Weight ]:
300.26300

[ Flash Point ]:
289ºC

[ Exact Mass ]:
300.06300

[ PSA ]:
107.22000

[ LogP ]:
1.32960

[ Vapour Pressure ]:
1.32E-17mmHg at 25°C

[ Index of Refraction ]:
1.765

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE3120000

CHEMICAL NAME :: Benz(b)indeno(1,2-d)pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-

CAS REGISTRY NUMBER :: 475-25-2

BEILSTEIN REFERENCE NO. :: 0093039

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H12-O6

MOLECULAR WEIGHT :: 300.28

WISWESSER LINE NOTATION :: T C6 B566 FV LO GH&TT&J EQ JQ NQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6653 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 760 (estimated) No. of Female Employees: 615 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.

FASEB J. 28(11) , 4792-805, (2014)

Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function...

Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.

Cell Death Dis. 6 , e1769, (2015)

Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregu...

The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats.

Biol. Pharm. Bull. 38 , 1345-51, (2015)

Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we ha...

2-((5-(4-bromophenyl)-1-(furan-2-ylmethyl)-1H-imidazol-2-yl)thio)-N-(thiazol-2-yl)acetamide
(E)-2-Cyano-3-[1-(4-methoxyphenyl)-2,5-dimethylpyrrol-3-yl]-N-[1-[4-(1,2,4-triazol-1-yl)phenyl]ethyl]prop-2-enamide
[(2,4-Difluorophenyl)methyl](2-ethoxyethyl)amine
2-((5-(4-bromophenyl)-1-(furan-2-ylmethyl)-1H-imidazol-2-yl)thio)-N-(4-methylthiazol-2-yl)acetamide
1-[4-(3-Bromobenzenesulfonyl)piperazin-1-yl]-5-(1,2-dithiolan-3-yl)pentan-1-one
2-((5-(4-bromophenyl)-1-(furan-2-ylmethyl)-1H-imidazol-2-yl)thio)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
(2-Ethoxyethyl)[(3-methylphenyl)methyl]amine
(2-Ethoxyethyl)[(4-ethylphenyl)methyl]amine
2-((5-(4-bromophenyl)-1-(furan-2-ylmethyl)-1H-imidazol-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
N-(1H-indazol-6-yl)-1-methyl-1H-1,2,3-triazole-4-carboxamide

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