Hematein
Modify Date: 2025-08-21 11:07:53
Hematein structure
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Common Name | Hematein | ||
|---|---|---|---|---|
| CAS Number | 475-25-2 | Molecular Weight | 300.26300 | |
| Density | 1.77g/cm3 | Boiling Point | 753.1ºC at 760mmHg | |
| Molecular Formula | C16H12O6 | Melting Point | 180ºC | |
| MSDS | USA | Flash Point | 289ºC | |
Use of HemateinHematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2]. |
| Name | 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one |
|---|---|
| Synonym | More Synonyms |
| Description | Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2]. |
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| Related Catalog | |
| Target |
CKII:0.74 μM (IC50) Akt Wnt |
| In Vitro | Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells[1]. Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells[1]. Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation[1]. Cell Viability Assay[1] Cell Line: A427 (HTB-53) cell line Concentration: 10-100 μM Incubation Time: 14 days Result: Inhibited cells growth. Apoptosis Analysis[1] Cell Line: A427 (HTB-53) cell line Concentration: 50 and 100 μM Incubation Time: 48 hours Result: Induced apoptosis in A427 lung cancer cells. Western Blot Analysis[1] Cell Line: A427 (HTB-53) cell line Concentration: 50 and 100 μM Incubation Time: 48 hours Result: Inhibited CK2-specific Akt phosphorylation. |
| In Vivo | Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts[1]. Animal Model: Female athymic BALB/c nude mice (6-week-old) [1] Dosage: 50 mg/kg Administration: Intraperitoneal injections; twice a week for 6 weeks Result: Inhibited tumor growth in A427 lung cancer cell xenografts. |
| References |
| Density | 1.77g/cm3 |
|---|---|
| Boiling Point | 753.1ºC at 760mmHg |
| Melting Point | 180ºC |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26300 |
| Flash Point | 289ºC |
| Exact Mass | 300.06300 |
| PSA | 107.22000 |
| LogP | 1.32960 |
| Vapour Pressure | 1.32E-17mmHg at 25°C |
| Index of Refraction | 1.765 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
FASEB J. 28(11) , 4792-805, (2014) Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function... |
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Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Cell Death Dis. 6 , e1769, (2015) Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregu... |
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The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats.
Biol. Pharm. Bull. 38 , 1345-51, (2015) Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we ha... |
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Name: Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4392930
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Name: Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coli...
Source: ChEMBL
Target: Chaperonin GroEL
External Id: CHEMBL4392931
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4392932
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Ro...
Source: ChEMBL
Target: 10 kDa heat shock protein, mitochondrial
External Id: CHEMBL4392933
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Name: Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherich...
Source: ChEMBL
Target: Co-chaperonin GroES
External Id: CHEMBL4392934
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Name: Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichi...
Source: ChEMBL
Target: Co-chaperonin GroES
External Id: CHEMBL4392935
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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| hydroxybrazilein |
| Haematein |
| EINECS 207-492-8 |