Naphthazarin
Suppliers
Names
[ CAS No. ]:
475-38-7
[ Name ]:
Naphthazarin
[Synonym ]:
5,8-Dihydroxy-1,4-naphthalenedione
EINECS 207-495-4
MFCD00001685
5,8-Dihydroxy-1,4-naphthoquinone
5,8-dihydroxynaphthalene-1,4-dione
Naphthazarin
Chemical & Physical Properties
[ Density]:
1.592g/cm3
[ Boiling Point ]:
498.2ºC at 760mmHg
[ Melting Point ]:
220-230 °C(lit.)
[ Molecular Formula ]:
C10H6O4
[ Molecular Weight ]:
190.15200
[ Flash Point ]:
269.2ºC
[ Exact Mass ]:
190.02700
[ PSA ]:
74.60000
[ LogP ]:
1.03300
[ Vapour Pressure ]:
1.51E-10mmHg at 25°C
[ Index of Refraction ]:
1.71
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL7970000
- CHEMICAL NAME :
- 1,4-Naphthoquinone, 5,8-dihydroxy-
- CAS REGISTRY NUMBER :
- 475-38-7
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C10-H6-O4
- MOLECULAR WEIGHT :
- 190.16
- WISWESSER LINE NOTATION :
- L66 BV EVJ GQ JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,25,1983
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25-S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
QL7970000
[ HS Code ]:
2914690090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914690090
[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Basic Clin Pharmacol Toxicol. 117 , 369-74, (2016)
The 1,4-naphthoquinone derivative naphthazarin may trigger apoptosis and is thus considered for the treatment of malignancy. On the other hand, naphthazarin decreases neurotoxicity. In analogy to apop...
Bioorg. Med. Chem. 17 , 2276-81, (2009)
Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular ar...
Int. J. Oncol. 46(4) , 1659-66, (2015)
Naphthazarin (Naph, DHNQ, 5,8-dihydroxy-l,4-naphthoquinone) is one of the naturally available 1,4-naphthoquinone derivatives that are well-known for their anti-inflammatory, antioxidant, antibacterial...