Naphthazarin
Naphthazarin structure
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Common Name | Naphthazarin | ||
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| CAS Number | 475-38-7 | Molecular Weight | 190.15200 | |
| Density | 1.592g/cm3 | Boiling Point | 498.2ºC at 760mmHg | |
| Molecular Formula | C10H6O4 | Melting Point | 220-230 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 269.2ºC | |
Use of NaphthazarinNaphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects[1][2]. |
| Name | naphthazarin |
|---|---|
| Synonym | More Synonyms |
| Description | Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.592g/cm3 |
|---|---|
| Boiling Point | 498.2ºC at 760mmHg |
| Melting Point | 220-230 °C(lit.) |
| Molecular Formula | C10H6O4 |
| Molecular Weight | 190.15200 |
| Flash Point | 269.2ºC |
| Exact Mass | 190.02700 |
| PSA | 74.60000 |
| LogP | 1.03300 |
| Vapour Pressure | 1.51E-10mmHg at 25°C |
| Index of Refraction | 1.71 |
| InChIKey | RQNVIKXOOKXAJQ-UHFFFAOYSA-N |
| SMILES | O=C1C=CC(=O)c2c(O)ccc(O)c21 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25-S37/39-S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | QL7970000 |
| HS Code | 2914690090 |
| Precursor 10 | |
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| DownStream 9 | |
CAS#:10075-68-0
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CAS#:21418-04-2
CAS#:81-64-1
CAS#:27573-16-6| HS Code | 2914690090 |
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| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Stimulation of Suicidal Erythrocyte Death by Naphthazarin.
Basic Clin Pharmacol Toxicol. 117 , 369-74, (2016) The 1,4-naphthoquinone derivative naphthazarin may trigger apoptosis and is thus considered for the treatment of malignancy. On the other hand, naphthazarin decreases neurotoxicity. In analogy to apop... |
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Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Bioorg. Med. Chem. 17 , 2276-81, (2009) Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular ar... |
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Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells.
Int. J. Oncol. 46(4) , 1659-66, (2015) Naphthazarin (Naph, DHNQ, 5,8-dihydroxy-l,4-naphthoquinone) is one of the naturally available 1,4-naphthoquinone derivatives that are well-known for their anti-inflammatory, antioxidant, antibacterial... |
| 5,8-Dihydroxy-1,4-naphthalenedione |
| EINECS 207-495-4 |
| MFCD00001685 |
| 5,8-Dihydroxy-1,4-naphthoquinone |
| 5,8-dihydroxynaphthalene-1,4-dione |
| Naphthazarin |