Colchiceine

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Names

[ CAS No. ]:
477-27-0

[ Name ]:
Colchiceine

[Synonym ]:
colchiceine

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
731.5ºC at 760mmHg

[ Melting Point ]:
172-174ºC

[ Molecular Formula ]:
C₂₁H₂₃NO₆

[ Molecular Weight ]:
385.41000

[ Flash Point ]:
396.2ºC

[ Exact Mass ]:
385.15300

[ PSA ]:
94.09000

[ LogP ]:
2.95950

[ Vapour Pressure ]:
1.83E-22mmHg at 25°C

[ Index of Refraction ]:
1.61

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0520000

CHEMICAL NAME :: Colchiceine

CAS REGISTRY NUMBER :: 477-27-0

BEILSTEIN REFERENCE NO. :: 2824078

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 nmol/L

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Trimethylcolchicinic acid
Ethanoic anhydride
(+/-)-N-deacetylcolchiceine
(+)-isocolchicine
N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate
(+/-)-N-deacetylisocolchicine
(+/-)-N-(trifluoroacetyl)deacetylisocolchicine
(+)-N-deacetylisocolchicine
7-(benzylideneamino)-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

DownStream

Trimethylcolchicinic acid methyl ether
Trimethylcolchicinic acid
(-)-Demecolcine
Colchicine
Acetamide, N- (5,6,7,10-tetrahydro-1,2,3, 9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)-, (S)-
COLCHICEINE, N-DEACETYL-N-METHYL-
N-Methylisocolchicine
N-Methylcolchicine
N-(10-ethoxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Acetamide,N-[(7S)-9-ethoxy-5,6,7,10-tetrahydro-1,2,3-trimethoxy-10-oxobenzo[a]heptalen-7-yl]-

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

colchiceine
colchiceine
COLCHICEINE-D3
DEACETYLCOLCHICEINE
N-Deacetyl Colchiceine
deacetamidocolchiceine
tert-butyl 4-amino-1,5-dimethyl-1H-pyrazole-3-carboxylate
1-[(Tert-butoxy)carbonyl]-2,4,6-trimethylpiperidine-3-carboxylic acid
Tert-butyl 2-(2-amino-1,3-thiazol-4-yl)-5,5-dimethylpiperidine-1-carboxylate
Tert-butyl 3-{pyrazolo[1,5-a]pyrimidin-2-yl}piperazine-1-carboxylate
2-[(3-Bromothiophen-2-yl)oxy]acetic acid
Tert-butyl 2-(2-fluoro-5-methylphenyl)piperazine-1-carboxylate
(2R)-2-{3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]propanamido}pentanoic acid
3-Azido-5-formyl-4-methylbenzoic acid
2-Hydroxy-3-[2-(methoxycarbonyl)phenyl]propanoic acid
tert-butyl N-{5-[1-(aminooxy)-2-methylpropan-2-yl]pyrimidin-2-yl}carbamate

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