Colchiceine

Modify Date: 2026-07-08 11:53:19

Colchiceine Structure
Colchiceine structure
 Common Name Colchiceine
CAS Number 477-27-0 Molecular Weight 385.41000
Density 1.31g/cm3 Boiling Point 731.5ºC at 760mmHg
Molecular Formula C21H23NO6 Melting Point 172-174ºC
MSDS N/A Flash Point 396.2ºC

 Names

Name Colchiceine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 731.5ºC at 760mmHg
Melting Point 172-174ºC
Molecular Formula C21H23NO6
Molecular Weight 385.41000
Flash Point 396.2ºC
Exact Mass 385.15300
PSA 94.09000
LogP 2.95950
Vapour Pressure 1.83E-22mmHg at 25°C
Index of Refraction 1.61
InChIKey PRGILOMAMBLWNG-HNNXBMFYSA-N
SMILES COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1C(NC(C)=O)CC2

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0520000
CHEMICAL NAME :
Colchiceine
CAS REGISTRY NUMBER :
477-27-0
BEILSTEIN REFERENCE NO. :
2824078
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C21-H23-N-O6
MOLECULAR WEIGHT :
385.45
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
43 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
250 nmol/L
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

 Safety Information

Hazard Codes T+
HS Code 2924299090

 Synthetic Route

Trimethylcolchicinic acid structure

Trimethylcolchi...

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Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
(+/-)-N-deacetylcolchiceine structure

(+/-)-N-deacety...

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199
(+)-isocolchicine structure

(+)-isocolchicine

CAS#:102419-93-2

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

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Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide structure

N-(1,2,3,10-tet...

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

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Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate structure

(R/S)-N-Deacety...

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(+/-)-N-deacetylisocolchicine structure

(+/-)-N-deacety...

CAS#:102491-74-7

~%

Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(+/-)-N-(trifluoroacetyl)deacetylisocolchicine structure

(+/-)-N-(triflu...

CAS#:102491-72-5

~%

Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(+)-N-deacetylisocolchicine structure

(+)-N-deacetyli...

CAS#:102419-92-1

~%

Colchiceine Structure

Colchiceine

CAS#:477-27-0

Learn More
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
7-(benzylideneamino)-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one structure

7-(benzylidenea...

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Colchiceine Structure

Colchiceine

CAS#:477-27-0

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Literature: Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 ColchiceineBioassay

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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
Name: Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
Source: NCGC
External Id: epac1-activator-v
Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
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 Synonyms

colchiceine
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