Colchiceine

Modify Date: 2025-08-22 19:20:26

Colchiceine structure	Common Name	Colchiceine
	CAS Number	477-27-0	Molecular Weight	385.41000
	Density	1.31g/cm3	Boiling Point	731.5ºC at 760mmHg
	Molecular Formula	C₂₁H₂₃NO₆	Melting Point	172-174ºC
	MSDS	N/A	Flash Point	396.2ºC

Name	Colchiceine
Synonym	More Synonyms

Density	1.31g/cm3
Boiling Point	731.5ºC at 760mmHg
Melting Point	172-174ºC
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41000
Flash Point	396.2ºC
Exact Mass	385.15300
PSA	94.09000
LogP	2.95950
Vapour Pressure	1.83E-22mmHg at 25°C
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0520000

CHEMICAL NAME :: Colchiceine

CAS REGISTRY NUMBER :: 477-27-0

BEILSTEIN REFERENCE NO. :: 2824078

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 nmol/L

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

Hazard Codes	T+
HS Code	2924299090

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Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

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