Safranin

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Names

[ CAS No. ]:
477-73-6

[ Name ]:
Safranin

[Synonym ]:
Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride (1:1)
Safranin T
safranin A
C.I. Basic Red 2 (8CI)
Safranine
safranin Y
3,7-Diamino-2,8-dimethyl-5-phenylphenazin-5-ium chloride
Basic Red 2
Gossypimine
Safranine O,certified
Safranin
EINECS 207-518-8
Hidaco safranine
MFCD00011759
Safranine O
Safranin O
Tolusafranine
Safranine O,high purity biological stain
Cotton Red
Safranin Y or A
Safranine-O chloride
Safranine T
Basic Red 2,Cotton Red,Gossypimine

Chemical & Physical Properties

[ Density]:
1.00 g/mL at 20 °C

[ Molecular Formula ]:
C20H19ClN4

[ Molecular Weight ]:
350.845

[ Flash Point ]:
46 °C

[ Exact Mass ]:
350.129822

[ PSA ]:
68.81000

[ LogP ]:
1.61230

[ Index of Refraction ]:
n20/D 1.339

[ Stability ]:
Stable.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SG1623000
CHEMICAL NAME :
Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride
CAS REGISTRY NUMBER :
477-73-6
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C20-H19-N4.Cl
MOLECULAR WEIGHT :
350.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28740 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24020 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
26940 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
2 mg/disc
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1441 No. of Facilities: 1027 (estimated) No. of Industries: 9 No. of Occupations: 18 No. of Employees: 4314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1441 No. of Facilities: 1253 (estimated) No. of Industries: 6 No. of Occupations: 10 No. of Employees: 22263 (estimated) No. of Female Employees: 14330 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
26-39-24/25-36-16

[ RIDADR ]:
UN 1170 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SG1623000

[ HS Code ]:
32041300

Synthetic Route

Precursor & DownStream

Precursor

  • o-Toluidine
  • 2,5-Diaminotoluene
  • 2,5-Cyclohexadiene-1,4-diimine,N1,N4-dichloro-2-methyl-
  • 4-methyl-N1-phenylbenzene-1,3-diamine

DownStream

  • 8-imino-3,7-dimethyl-10-phenylphenazin-2-amine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • safranin O
  • Safranine 8B
  • SAFRANIN BLUE
  • Safranin Bluish
  • {1-[3-Methoxy-5-(methoxymethyl)-2-methylpyridin-4-yl]cyclopropyl}methanol
  • O-[2-(4-ethylcyclohexyl)propan-2-yl]hydroxylamine
  • 1-[1-(2-Methylquinolin-6-yl)cyclopropyl]cyclopropan-1-amine
  • Methyl[2-(2-methylquinolin-6-yl)propan-2-yl]amine
  • 2,2-Dimethyl-3-(2-methylquinolin-6-yl)cyclopropan-1-amine
  • 2-Methyl-6-(prop-2-yn-1-yl)quinoline
  • {1-[(1-methyl-1H-indol-6-yl)methyl]cyclopropyl}methanol
  • 3-{6,6-Dimethylbicyclo[3.1.1]heptan-2-yl}-1,2-oxazole-5-carboxylic acid
  • 5-(2-Isocyanatopropyl)-2,3-dihydro-1-benzofuran
  • 3-[(2,4,6-Trimethylphenyl)methyl]but-3-en-1-amine
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