Quipazine

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Names

[ CAS No. ]:
4774-24-7

[ Name ]:
Quipazine

[Synonym ]:
Quinoline, 2-(1-piperazinyl)-
2-(piperazin-1-yl)quinoline
Quipazine
MFCD00242605
2-(1-Piperazinyl)quinoline
2-piperazin-1-yl-quinoline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
403.7±25.0 °C at 760 mmHg

[ Melting Point ]:
120-122 °C(lit.)

[ Molecular Formula ]:
C21H23N3O8

[ Molecular Weight ]:
213.278

[ Flash Point ]:
198.0±23.2 °C

[ Exact Mass ]:
213.126602

[ PSA ]:
177.36000

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.629

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC2513500
CHEMICAL NAME :
Quinoline, 2-(1-piperazinyl)-
CAS REGISTRY NUMBER :
4774-24-7
BEILSTEIN REFERENCE NO. :
0196945
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H15-N3
MOLECULAR WEIGHT :
213.31
WISWESSER LINE NOTATION :
T66 BNJ C- AT6N DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
296 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 3,357,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1394,1985

Safety Information

[ RTECS ]:
VC2513500

Synthetic Route

Precursor & DownStream

Precursor

  • Piperazine
  • Chloroquinoline
  • 2-(4-Cyano-1-piperazinyl)quinoline
  • Acetanilide
  • quinolone

DownStream

  • 2-(3-(4-(2-quinolyl))-1-piperazinyl)propyl-1,2,4-triazolo(4,3-a)pyridin-3(2H)-one

Related Compounds

  • Quipazine maleate
  • N-Methylquipazine
  • Quipazine dimaleate
  • Quipazine dimaleate
  • 6-nitroquipazine maleate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • N-(4-methyl-5-phenyl-1,3-thiazol-2-yl)-2-(methylsulfanyl)pyridine-3-carboxamide
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • (E)-2-(4-chlorophenyl)-N-(2-pyridin-2-ylethyl)ethenesulfonamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine