Quipazine

Modify Date: 2024-01-02 10:37:28

Quipazine structure	Common Name	Quipazine
	CAS Number	4774-24-7	Molecular Weight	213.278
	Density	1.2±0.1 g/cm3	Boiling Point	403.7±25.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₃N₃O₈	Melting Point	120-122 °C(lit.)
	MSDS	N/A	Flash Point	198.0±23.2 °C

Use of Quipazine

Quipazine is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research[1][2][3][4].

Name	Quipazine
Synonym	More Synonyms

Description	Quipazine is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research[1][2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> SARS-CoV Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Quipazine 对 5-HT1 和 5-HT2 具有结合效能，Ki 值均为 230 nM[3]。 Quipazine 取代大鼠内皮层中 5-HT3R 的 [3H]GR65630，Ki 值为 1.4 nM[3]。 Quipazine 对大鼠迷走神经具有拮抗作用，对 5-HT2，5-HT1 以及抑制 5-HT 释放的 pIC50 值分别为 6.1，6.49 和 6.17[4]。
In Vivo	Quipazine (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择[1]。
References	[1]. Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. [2]. Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. [3]. Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. [4]. Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38.

Density	1.2±0.1 g/cm3
Boiling Point	403.7±25.0 °C at 760 mmHg
Melting Point	120-122 °C(lit.)
Molecular Formula	C₂₁H₂₃N₃O₈
Molecular Weight	213.278
Flash Point	198.0±23.2 °C
Exact Mass	213.126602
PSA	177.36000
LogP	1.59
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.629

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC2513500

CHEMICAL NAME :: Quinoline, 2-(1-piperazinyl)-

CAS REGISTRY NUMBER :: 4774-24-7

BEILSTEIN REFERENCE NO. :: 0196945

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H15-N3

MOLECULAR WEIGHT :: 213.31

WISWESSER LINE NOTATION :: T66 BNJ C- AT6N DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 296 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 3,357,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1394,1985

RTECS	VC2513500

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Literature: Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Minato, Kouichi; Sato, Michitaka Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7549 - 7563

2-(4-Cyano-1-pi...

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Quipazine

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Literature: Jensen, Jorgen A.; Pedersen, Erik B. Archiv der Pharmazie (Weinheim, Germany), 1987 , vol. 320, # 10 p. 1088 - 1092

Acetanilide

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Piperazine

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quinolone

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Literature: Vorbrueggen, Helmut; Krolikiewicz, Konrad Chemische Berichte, 1984 , vol. 117, # 4 p. 1523 - 1541

Precursor 5
CAS#:110-85-0 Piperazine CAS#:612-62-4 Chloroquinoline CAS#:112036-71-2 2-(4-Cyano-1-pi... CAS#:103-84-4 Acetanilide
CAS#:59-31-4 quinolone
DownStream 1
CAS#:139477-46-6 2-(3-(4-(2-quin...

Quinoline, 2-(1-piperazinyl)-

2-(piperazin-1-yl)quinoline

Quipazine

MFCD00242605

2-(1-Piperazinyl)quinoline

2-piperazin-1-yl-quinoline

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Quipazine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Quipazine
Price: ￥606.0/250mg ￥1506.0/1g
Purity: 97.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Quipazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Quipazine

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