Juglone

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Names

[ CAS No. ]:
481-39-0

[ Name ]:
Juglone

[Synonym ]:
Nucin
Juglone
EINECS 207-567-5
5-Hydroxy-1,4-naphthalenedione
C.I. Natural Brown 7
5-hydroxynaphthalene-1,4-dione
Regianin
CI 75500
5-hydroxy-1,4-dihydronaphthalene-1,4-dione
5-Hydroxy-1,4-naphthochinone
1,4-Naphthalenedione, 5-hydroxy-
5-HNQ
5-Hydroxy-p-naphthoquinone
MFCD00001684
5-Hydroxy-1,4-naphthoquinone

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
385.8±42.0 °C at 760 mmHg

[ Melting Point ]:
161-163 °C(lit.)

[ Molecular Formula ]:
C₁₀H₆O₃

[ Molecular Weight ]:
174.153

[ Flash Point ]:
201.3±24.4 °C

[ Exact Mass ]:
174.031693

[ PSA ]:
54.37000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.662

[ Storage condition ]:
Refrigerator (+4°C)

[ Water Solubility ]:
SOLUBLE IN HOT WATER

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5775000

CHEMICAL NAME :: 1,4-Naphthalenedione, 5-hydroxy-

CAS REGISTRY NUMBER :: 481-39-0

BEILSTEIN REFERENCE NO. :: 1909764

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H6-O3

MOLECULAR WEIGHT :: 174.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 394 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 10 mg/kg

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S22-S26-S36/37/39-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
QJ5775000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Aloeemodin
Obtusifolin
Chrysophanic acid
8-hydroxy-1-methoxy-3-methylanthracene-9,10-dione
2-chloro-8-hydroxynaphthalene-1,4-dione
(8-acetyloxy-3-methyl-9,10-dioxo-anthracen-1-yl) acetate
Plumbagin
5-hydroxy-3-methyl-1,4-naphthoquinone
2,3-dimethyl-5-hydroxy-1,4-naphthoquinone
1-HYDROXYANTHRAQUINONE

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Determination of the Juglone Content of Juglans regia Leaves by GC/MS.

Nat. Prod. Commun. 10 , 1239-42, (2015)

The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic ext...