Hydroxymetronidazole

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Names

[ CAS No. ]:
4812-40-2

[ Name ]:
Hydroxymetronidazole

[Synonym ]:
2-[2-(hydroxymethyl)-5-nitroimidazol-1-yl]ethanol

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
475.2ºC at 760mmHg

[ Melting Point ]:
118-121ºC

[ Molecular Formula ]:
C6H9N3O4

[ Molecular Weight ]:
187.15300

[ Flash Point ]:
241.2ºC

[ Exact Mass ]:
187.05900

[ PSA ]:
104.10000

[ Index of Refraction ]:
1.643

[ Storage condition ]:
-20?C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI5568000
CHEMICAL NAME :
Imidazole-1-ethanol, 2-hydroxymethyl-5-nitro-
CAS REGISTRY NUMBER :
4812-40-2
BEILSTEIN REFERENCE NO. :
0883934
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H9-N3-O4
MOLECULAR WEIGHT :
187.18
WISWESSER LINE NOTATION :
T5N CNJ A2Q B1Q ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Klebsiella pneumoniae
DOSE/DURATION :
10 umol/L/20H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NI5568000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl-(2-hydroxymethyl-5-nitro)imidazolylacetate
  • 2-(2-(hydroxymethyl)-5-nitro-1H-imidazol-1-yl)acetic acid
  • ethyl 2-(2-methyl-5-nitroimidazol-1-yl)acetate

DownStream

Articles

Development of a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for nitroimidazoles in edible animal tissues and feeds.

J. Pharm. Biomed. Anal. 120 , 84-91, (2016)

The misuse of nitroimidazoles (NDZs) can lead to NDZs residues in edible animal tissues, which would be harmful to consumer health. To quickly monitor NDZs residues in edible animal tissues and feed, ...

Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry.

Food Chem. 197 , 571-80, (2015)

A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphona...

Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.

Clin. Chem. 30(5) , 784-7, (1984)

Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de...


More Articles

Related Compounds

  • Hydroxymetronidazole-d4
  • 4-Amino-5-(difluoromethyl)-6-iodopyridine-2-sulfonyl chloride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-(Aminomethyl)-3-(difluoromethyl)-5-methoxypyridin-2-amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 7-Bromo-1,2-benzoxazole-4-carboxylic acid
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde