Hydroxymetronidazole
Hydroxymetronidazole structure
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Common Name | Hydroxymetronidazole | ||
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| CAS Number | 4812-40-2 | Molecular Weight | 187.15300 | |
| Density | 1.61g/cm3 | Boiling Point | 475.2ºC at 760mmHg | |
| Molecular Formula | C6H9N3O4 | Melting Point | 118-121ºC | |
| MSDS | Chinese USA | Flash Point | 241.2ºC | |
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Development of a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for nitroimidazoles in edible animal tissues and feeds.
J. Pharm. Biomed. Anal. 120 , 84-91, (2016) The misuse of nitroimidazoles (NDZs) can lead to NDZs residues in edible animal tissues, which would be harmful to consumer health. To quickly monitor NDZs residues in edible animal tissues and feed, a monoclonal antibody-based indirect competitive enzyme-lin... |
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Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry.
Food Chem. 197 , 571-80, (2015) A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphonamides (17), nitroimidazoles (9), amphenicols (2), cephalosp... |
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Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.
Clin. Chem. 30(5) , 784-7, (1984) Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples deproteinized with trichloroacetic acid (50 g/L final concent... |
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Steady-state pharmacokinetics of metronidazole in Crohn's disease.
Biopharm. Drug Dispos. 8(3) , 249-59, (1987) The pharmacokinetics of metronidazole (MTZ) were studied in six Crohn's disease patients after multiple oral daily doses of 250, 500, 750, and 1000 mg day-1. Pharmacokinetic indices were found to be independent of the dose administered. The half-life, volume ... |
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Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury.
Aliment. Pharmacol. Ther. 13(10) , 1335-41, (1999) To evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole (OH-MET/MET) ratios as a dynamic liver function test in ethanol abusers with or without liver cirrhosis.Metronidazole was administered intravenously for 20 min to healthy volunteers, and... |
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Intravenous metronidazole in the newborn.
Arch. Dis. Child. 58(7) , 529-31, (1983) Twenty four neonates at high risk of anaerobic sepsis were treated with intravenous metronidazole, 7.5 mg/kg, 8 hourly, for a mean period of 5 days. The highest observed concentration after the first dose (mean +/- SD) 9.6 +/- 4.0 mg/l (56.1 +/- 23.4 mumol/l)... |
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Metronidazole elimination is preserved in the elderly.
Hum. Exp. Toxicol. 9(3) , 155-9, (1990) 1 The disposition of metronidazole and its major metabolites was compared in 11 subjects aged 86 +/- 6 years and 8 aged 30 +/- 6 years. 2 The plasma clearance of metronidazole was 1.20 +/- 0.53 and 1.25 +/- 0.22 ml min-1 kg-1, the volume of distribution 0.77 ... |
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Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites.
Sex. Transm. Dis. 7(4) , 157-60, (1980) The susceptibilities of strains of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxyethyl]-2-hydroxymethyl-5-nitroimidazole) ("hydroxy" metabol... |
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The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice.
Br. J. Clin. Pharmacol. 44(3) , 245-53, (1997) To evaluate the effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in plasma, gastric juice and saliva following intravenous infusion or oral dosing of metronidazole.Eight volunteers received single doses of metronidazole (... |
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In vitro activity of azlocillin, metronidazole and its hydroxy metabolite against anaerobes. Bacteriostatic synergism studies.
Arzneimittelforschung 33(4) , 574-7, (1983) The in vitro inhibitory activity of azlocillin (Securopen), metronidazole (Cloni) and its hydroxy metabolite was determined against 27 gram-negative and 13 gram-positive species of anaerobes by means of agar dilution tests. The 63 anaerobic strains were also ... |