Ninhydrin

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Names

[ CAS No. ]:
485-47-2

[ Name ]:
Ninhydrin

[Synonym ]:
2,2-Dihydroxy-1H-indene-1,3(2H)-dione
Triketohydrinden Hydrate
Ninhydrin
2,2-Dihydroxy-1,3-indanedione
Ninhydrin,spectrophotometric grade
MFCD00003791
Ninhydrin Spray
Ningidrin
indane-1,2,3-trione monohydrate
NyNhydriN
NinhydrinGr
1,2,3-Indanetrione monohydrate
Trioxohydrindene monohydrate
Ninhydrin,ozone friendly ready to use spray
1H-Indene-1,2,3-trione hydrate
Ninhydrin (contains Acetic Acid) Ethanol
1,2,3-Indantrione, 2-hydrate
EINECS 207-618-1
NINHYDRINE
1,2,3-triketohydrindene hydrate
1H-Indene-1,3(2H)-dione, 2,2-dihydroxy-
2,2-dihydroxy-2H-indene-1,3-dione
Ninhydrin hydrate
NinhydrinA.R.
NIN
Ninthydrin
1,3-Indandione, 2,2-dihydroxy-
1,2,3-Indantrione monohydrate
1,2,3-Indantrione monohydrate,2,2-Dihydroxy-1,3-indanedione,Trioxohydrindene monohydrate

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
449.3±45.0 °C at 760 mmHg

[ Melting Point ]:
250 °C (dec.)(lit.)

[ Molecular Formula ]:
C9H6O4

[ Molecular Weight ]:
178.141

[ Flash Point ]:
239.7±25.2 °C

[ Exact Mass ]:
178.026611

[ PSA ]:
74.60000

[ LogP ]:
1.07

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.737

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with amines, alkalies, strong bases. Light-sensitive.

[ Water Solubility ]:
0.1-0.5 g/100 mL at 20 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK5425000
CHEMICAL NAME :
1,3-Indandione, 2,2-dihydroxy-
CAS REGISTRY NUMBER :
485-47-2
BEILSTEIN REFERENCE NO. :
1910963
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H6-O4
MOLECULAR WEIGHT :
178.15
WISWESSER LINE NOTATION :
L56 BV DV CHJ CQ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 151,719,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1175 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 594 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1175 No. of Facilities: 476 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 5565 (estimated) No. of Female Employees: 4002 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S28A-S45-S16

[ RIDADR ]:
UN 1170 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
NK5425000

[ Hazard Class ]:
3.0

[ HS Code ]:
2915900090

Synthetic Route

Precursor & DownStream

Precursor

  • 1,3-INDANDIONE
  • Benzyl chloroformate
  • phenyliodonium betaine of 1,3-indanedione
  • 2,2-diethoxyindene-1,3-dione
  • 2,2-dimethoxy-1,3-indanedione
  • CARMINIC ACID
  • Vanillin
  • 3-Bromo-1H-inden-1-one
  • 2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile
  • 1-Indanone

DownStream

  • N-[2-(hydroxyamino)-3-nitrosoinden-1-ylidene]hydroxylamine
  • 3-methoxy-3H-isobenzofuran-1-one
  • Hydrindantin
  • azine-bisindandione
  • 3-benzhydrylideneisobenzofuran-1-one
  • 1,3-Indandione, 2-diazo-
  • D-Arabinose
  • Malonic acid

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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Related Compounds

  • Reduced Ninhydrin
  • benzo[f]ninhydrin
  • Ninhydrin-dimethylketal
  • Benzo[f]ninhydrin monohydrate
  • Tert-butyl 6-oxo-5-oxa-2,7-diazaspiro[3.5]nonane-2-carboxylate
  • N-{[2-(1-ethoxyethenyl)pyridin-3-yl]methyl}cyclopropanamine
  • N-{[3-(1-ethoxyethenyl)pyridin-4-yl]methyl}cyclopropanamine
  • 4-Bromo-2-tert-butyl-6-(1-ethoxyethenyl)pyrimidine
  • Pyridine, 2,3-dimethyl-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
  • 2,4-Dichloro-5-(chloromethyl)benzene-1-sulfonyl fluoride
  • 4-[4-(benzyloxy)-2,6-difluorophenyl]-1-methyl-1H-pyrazole
  • 1-(but-3-en-1-yl)-1H-imidazol-2-amine
  • 1-(2-Amino-1,3-thiazol-5-yl)-2-methylprop-2-en-1-one
  • O-[1-(4-chloro-2-fluorophenyl)ethyl]hydroxylamine