Amiphenazole

Names

[ CAS No. ]:
490-55-1

[ Name ]:
Amiphenazole

[Synonym ]:
5-phenyl-thiazole-2,4-diyldiamine
Fenamizol
Dizol
Phenamizol
2,4-diamino-5-phenylthiazole
Amiphenazole
Daptazile
5-phenyl-thiazole-2,4-diamine
Amifenazol
Phenamizole
Amiphenazol
Daftazol
5-Phenyl-thiazol-2,4-diyldiamin

Chemical & Physical Properties

[ Density]:
1.347g/cm3

[ Boiling Point ]:
413.3ºC at 760mmHg

[ Molecular Formula ]:
C9H9N3S

[ Molecular Weight ]:
191.25300

[ Flash Point ]:
203.7ºC

[ Exact Mass ]:
191.05200

[ PSA ]:
93.17000

[ LogP ]:
3.13690

[ Vapour Pressure ]:
4.86E-07mmHg at 25°C

[ Index of Refraction ]:
1.715

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ4020000
CHEMICAL NAME :
Thiazole, 2,4-diamino-5-phenyl-
CAS REGISTRY NUMBER :
490-55-1
BEILSTEIN REFERENCE NO. :
0157088
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H9-N3-S
MOLECULAR WEIGHT :
191.27
WISWESSER LINE NOTATION :
T5N CSJ BZ DR& EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1125,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory obstruction Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,489,1973

Safety Information

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzeneacetonitrile,a-[(phenylsulfonyl)oxy]-
  • Bromobenzyl cyanide
  • Sodium cyanide
  • Benzaldehyde

DownStream

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

  • (1S)-1-[1-(2,2-dimethylpropyl)-3-(propan-2-yl)-1H-pyrazol-5-yl]ethan-1-amine
  • (2S)-4-bromobutan-2-aminehydrobromide
  • 2-[3-[2-(Dimethylamino)ethyl]-6,7-dihydro-[1,4]dioxino[2,3-f]benzimidazol-2-yl]ethanamine;trihydrochloride
  • 1-methyl-N-phenyl-2-oxabicyclo[2.1.1]hexane-4-carboxamide
  • 2,2-Difluoro-1-(4-methylpyrimidin-5-yl)ethan-1-ol
  • (2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{3,5-difluoro-4-[(3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl]phenoxy}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
  • 2-{1-[2-(Methoxycarbonyl)phenyl]cyclopropyl}acetic acid
  • 5-(3-Fluoro-2,6-dimethoxyphenyl)-1,3-oxazol-2-amine
  • 1-[1-(3-Fluoro-2,6-dimethoxyphenyl)cyclopropyl]ethan-1-ol
  • (3S)-3-hydroxy-5-methoxy-5-methylhexanoic acid
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