Kynurenic acid

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Names

[ CAS No. ]:
492-27-3

[ Name ]:
Kynurenic acid

[Synonym ]:
4-Hydroxyquinaldic Acid
2-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-
4-Oxo-1,4-dihydroquinoline-2-carboxylic acid
4-hydroxy-Quinaldic acid
2-Carboxy-4-hydroxyquinoline
1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID
4-Hydroxy-2-quinolincarboxylic acid
4-Hydroxyquinoline-2-carboxylic Acid Hydrate
4-Hydroxyquinoline-2-carboxylic acid
4-Oxo-1,4-dihydro-2-quinolinecarboxylic acid
Kynurenic acid
EINECS 207-751-5
MFCD00006753

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
358.4±42.0 °C at 760 mmHg

[ Melting Point ]:
275 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₇NO₃

[ Molecular Weight ]:
189.167

[ Flash Point ]:
170.5±27.9 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
70.42000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.639

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UZ9300000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Kynurenine
L-Kynurenine
cusparine
4-phenylmethoxyquinoline-2-carboxylic acid
4-(2-nitrophenyl)-2,4-dioxobutanoic acid
2′-Nitroacetophenone
4-benzyloxy-quinoline-2-carbonitrile
4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester

DownStream

leucoline
4-Bromoquinoline-2-carboxylic acid
4(1H)-Quinolinone
2-Quinolinecarboxylicacid,3,4-dihydroxy-(9CI)
CHEMBRDG-BB 4014212
4-phenylmethoxyquinoline-2-carboxylic acid

Articles

Lipocalin 2 modulates the cellular response to amyloid beta.

Cell Death Differ. 21(10) , 1588-99, (2014)

The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given the...

From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience.

J. Neurosci. 35 , 15903-15, (2015)

Arousal and stress critically regulate memory formation and retention. Increasing levels of stress produce an inverted U-shaped effect on cognitive performance, including the retention of explicit mem...

Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.

J. Nutr. 145(1) , 87-95, (2015)

The use of oral contraceptives (OCs) has been associated with low plasma pyridoxal 5'-phosphate (PLP). The functional consequences are unclear.To determine whether functional vitamin B-6 insufficiency...

Kynurenic Acid-d5
Kynurenic acid sodium
Kynurenic acid ethyl ester
Kynurenic acid,3-chloro- (5CI)
5-iodo-7-chloro-kynurenic acid
Kynurenic acid,3,7-dichloro- (5CI)
2-Fluoro-5-(thiophen-2-yl)benzaldehyde
2-{[(Thiophen-2-ylmethyl)amino]methyl}phenol
N-Butyl-3-(3,5-dichlorophenyl)-2,4-dioxo-1-imidazolidinecarboxamide
3-[(2-Thiazolylamino)sulfonyl]benzoic acid
10,13-Difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0,3,7]trideca-1(9),10,12-triene
N-[4-[(Ethylamino)sulfonyl]benzoyl]glycine
4-(4-Chloro-1,2,5-thiadiazol-3-yl)benzonitrile
2-(2,6-Dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetohydrazide
4-(2-Fluorophenyl)-2-oxo-3(2H)-thiazolepropanoic acid
2H-Pyrrol-2-one, 1,3-dihydro-5-(3-methylbutyl)-

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