2-Hydroxy-4-methylbenzoic acid

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Names

[ CAS No. ]:
50-85-1

[ Name ]:
2-Hydroxy-4-methylbenzoic acid

[Synonym ]:
2-Hydroxy-4-methylbenzoic acid,m-Cresotic acid
4-Methylsalicylic acid
2-Hydroxy-4-methyl-benzoic acid
EINECS 200-068-3
2-Hydroxy-p-toluic Acid
Benzoic acid, 2-hydroxy-4-methyl-
m-Cresotic acid
2-Hydroxy-4-methylbenzoic acid
MFCD00002454

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
315.2±30.0 °C at 760 mmHg

[ Melting Point ]:
173-177 °C(lit.)

[ Molecular Formula ]:
C8H8O3

[ Molecular Weight ]:
152.147

[ Flash Point ]:
158.6±21.1 °C

[ Exact Mass ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
2.52

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.600

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GP3920100
CHEMICAL NAME :
2,4-Cresotic acid
CAS REGISTRY NUMBER :
50-85-1
BEILSTEIN REFERENCE NO. :
2208140
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16
WISWESSER LINE NOTATION :
QVR BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,289,1970

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GP3920100

[ HS Code ]:
2918219000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Methylbenzoic acid
  • 2-Chloro-4-methylbenzoic acid
  • Carbon dioxide
  • m-Cresol
  • Potassium hydrogen carbonate
  • Pyridinium,1-[2-(2-hydroxy-4-methylphenyl)-2-oxoethyl]-, iodide (1:1)
  • 2'-Hydroxy-4'-methylacetophenone
  • 2-hydroxy-2-(2-hydroxy-p-tolyl)-1,3-Indandione
  • 2H-1-Benzopyran-2-one,4,7-dimethyl-
  • 2-Hydroxy-4-methylbenzaldehyde

DownStream

  • Methyl 2-hydroxy-4-methylbenzoate
  • 2-Acetoxy-4-methylbenzoic acid
  • Tribromometacresol
  • 2,5-Cyclohexadiene-1,4-dione,2,3,5-tribromo-6-methyl-
  • 5-bromo-2-hydroxy-4-methyl-benzoic acid
  • 3,5-dibromo-2-hydroxy-4-methyl-benzoic acid
  • 3,6-dimethylxanthen-9-one
  • (4-Carboxy-3-ethoxy)phenyl Acetic Acid
  • m-Cresol
  • Carbon dioxide

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

[New highly phosphorescent heteroleptic tris-cyclometalated iridium (III) complexes: synthesis and photophysical characterization].

Guang Pu Xue Yu Guang Pu Fen Xi 30(1) , 170-3, (2010)

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)2 Ir(LX) (ppy==2-phenylpyridine, LX==Sal (salicylic acid), Msal (4-methylsalicylic acid), FSal(4-trifluoro methyl salicylic acid)) was ...

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochem. Pharmacol. 52 , 1643-1646, (1996)

Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...


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Related Compounds

  • 5-bromo-2-hydroxy-4-methylbenzoic acid
  • 5-ethyl-2-hydroxy-4-methylbenzoic acid
  • 3,5-dibromo-2-hydroxy-4-methylbenzoic acid
  • 2-hydroxy-4-methylbenzoic acid methyl ester
  • 3,5-DIAMINO-2-HYDROXY-4-METHYLBENZOIC ACID METHYL ESTER
  • 5-[[4'-[[6-amino-5-(1H-benzotriazol-4-ylazo)-1-hydroxy-3-sulpho-2-naphthyl]azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-2-hydroxy-4-methylbenzoic acid
  • N-Phenyl-N-(phenylmethyl)-I(2)-alanine
  • 4-Bromo-2-{3-[(2-ethyl-6-methylphenyl)amino]-5,7-dimethylimidazo[1,2-a]pyrimidin-2-yl}phenol
  • Thieno[3,4-c]pyridine-6-carboxylic acid
  • 3-Ethyl-8-[(2-hydroxy-4-methoxyphenyl)methyl]-1-(3-methylbutyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
  • 15-Aminopentadecan-1-ol
  • 3-Benzylsulfonyl-1,1-dimethylurea
  • 5-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazole
  • 5-Fluoro-2,3-dihydro-1h-pyrrolo[2,1-b]quinazolin-9-one
  • 1-Benzylsulfonyl-1,3-dimethylurea
  • 3-(4-Methylthiophen-2-yl)-N-(3-morpholinopropyl)-5-(morpholinosulfonyl)benzamide
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