2-Hydroxy-4-methylbenzoic acid

Modify Date: 2025-08-20 11:24:42

2-Hydroxy-4-methylbenzoic acid Structure
2-Hydroxy-4-methylbenzoic acid structure
 Common Name 2-Hydroxy-4-methylbenzoic acid
CAS Number 50-85-1 Molecular Weight 152.147
Density 1.3±0.1 g/cm3 Boiling Point 315.2±30.0 °C at 760 mmHg
Molecular Formula C8H8O3 Melting Point 173-177 °C(lit.)
MSDS Chinese USA Flash Point 158.6±21.1 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2-Hydroxy-4-methylbenzoic acid


4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor[1].

 Names

Name 4-methylsalicylic acid
Synonym More Synonyms

 2-Hydroxy-4-methylbenzoic acid Biological Activity

Description 4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor[1].
Related Catalog
References

[1]. Mumtaz A, et al. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies. Bioorg Chem. 2020 Aug;101:103996.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 315.2±30.0 °C at 760 mmHg
Melting Point 173-177 °C(lit.)
Molecular Formula C8H8O3
Molecular Weight 152.147
Flash Point 158.6±21.1 °C
Exact Mass 152.047348
PSA 57.53000
LogP 2.52
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.600

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GP3920100
CHEMICAL NAME :
2,4-Cresotic acid
CAS REGISTRY NUMBER :
50-85-1
BEILSTEIN REFERENCE NO. :
2208140
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16
WISWESSER LINE NOTATION :
QVR BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,289,1970

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GP3920100
HS Code 2918219000

 Synthetic Route

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles2

More Articles
[New highly phosphorescent heteroleptic tris-cyclometalated iridium (III) complexes: synthesis and photophysical characterization].

Guang Pu Xue Yu Guang Pu Fen Xi 30(1) , 170-3, (2010)

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)2 Ir(LX) (ppy==2-phenylpyridine, LX==Sal (salicylic acid), Msal (4-methylsalicylic acid), FSal(4-trifluoro methyl salicylic acid)) was ...

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochem. Pharmacol. 52 , 1643-1646, (1996)

Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...

 Synonyms

2-Hydroxy-4-methylbenzoic acid,m-Cresotic acid
4-Methylsalicylic acid
2-Hydroxy-4-methyl-benzoic acid
EINECS 200-068-3
2-Hydroxy-p-toluic Acid
Benzoic acid, 2-hydroxy-4-methyl-
m-Cresotic acid
2-Hydroxy-4-methylbenzoic acid
MFCD00002454
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