2-Hydroxy-4-methylbenzoic acid

Modify Date: 2025-08-20 11:24:42

2-Hydroxy-4-methylbenzoic acid structure	Common Name	2-Hydroxy-4-methylbenzoic acid
	CAS Number	50-85-1	Molecular Weight	152.147
	Density	1.3±0.1 g/cm3	Boiling Point	315.2±30.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₃	Melting Point	173-177 °C(lit.)
	MSDS	Chinese USA	Flash Point	158.6±21.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-Hydroxy-4-methylbenzoic acid

4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor[1].

Name	4-methylsalicylic acid
Synonym	More Synonyms

Description	4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor[1].
Related Catalog	Signaling Pathways >> Apoptosis >> IAP Research Areas >> Inflammation/Immunology
References	[1]. Mumtaz A, et al. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies. Bioorg Chem. 2020 Aug;101:103996.

Density	1.3±0.1 g/cm3
Boiling Point	315.2±30.0 °C at 760 mmHg
Melting Point	173-177 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	158.6±21.1 °C
Exact Mass	152.047348
PSA	57.53000
LogP	2.52
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.600

2-Hydroxy-4-methylbenzoic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP3920100

CHEMICAL NAME :: 2,4-Cresotic acid

CAS REGISTRY NUMBER :: 50-85-1

BEILSTEIN REFERENCE NO. :: 2208140

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QVR BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,289,1970

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GP3920100
HS Code	2918219000

Precursor 10
CAS#:99-94-5 4-Methylbenzoic acid CAS#:7697-25-8 2-Chloro-4-meth... CAS#:124-38-9 Carbon dioxide CAS#:108-39-4 m-Cresol
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DownStream 10
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CAS#:108-39-4 m-Cresol CAS#:124-38-9 Carbon dioxide

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

[New highly phosphorescent heteroleptic tris-cyclometalated iridium (III) complexes: synthesis and photophysical characterization].

Guang Pu Xue Yu Guang Pu Fen Xi 30(1) , 170-3, (2010)

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)2 Ir(LX) (ppy==2-phenylpyridine, LX==Sal (salicylic acid), Msal (4-methylsalicylic acid), FSal(4-trifluoro methyl salicylic acid)) was ...

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochem. Pharmacol. 52 , 1643-1646, (1996)

Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...

2-Hydroxy-4-methylbenzoic acid,m-Cresotic acid

4-Methylsalicylic acid

2-Hydroxy-4-methyl-benzoic acid

EINECS 200-068-3

2-Hydroxy-p-toluic Acid

Benzoic acid, 2-hydroxy-4-methyl-

m-Cresotic acid

2-Hydroxy-4-methylbenzoic acid

MFCD00002454

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Hydroxy-4-methylbenzoic acid
Price: Check
Purity: 99.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Hydroxy-4-methylbenzoic acid
Price: ￥348.0/100g ￥118.0/25g
Purity: 99.0%
Delivery: 2 Day
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DC Chemicals Limited
China
Product Name: 4-Methylsalicylic acid
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Methylsalicylic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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