3-hydroxy-3-methylglutaric acid

Suppliers

Names

[ CAS No. ]:
503-49-1

[ Name ]:
3-hydroxy-3-methylglutaric acid

[Synonym ]:
EINECS 207-971-1
MFCD00002712
3-hydroxy-3-methylpentanedioic acid
3-Hydroxy-3-Methylglutaric Acid
Meglutol

Chemical & Physical Properties

[ Density]:
1.417 g/cm3

[ Boiling Point ]:
120 °C / 13mmHg

[ Melting Point ]:
105-108 °C(lit.)

[ Molecular Formula ]:
C6H10O5

[ Molecular Weight ]:
162.14100

[ Flash Point ]:
182.2ºC

[ Exact Mass ]:
162.05300

[ PSA ]:
94.83000

[ Index of Refraction ]:
1.512

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA3753000
CHEMICAL NAME :
Glutaric acid, 3-hydroxy-3-methyl-
CAS REGISTRY NUMBER :
503-49-1
BEILSTEIN REFERENCE NO. :
1769194
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H10-O5
MOLECULAR WEIGHT :
162.16
WISWESSER LINE NOTATION :
QV1XQ1&1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7330 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3230 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MA3753000

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Methylpentane-1,3,5-triol
  • ditert-butyl 3-hydroxy-3-methylpentanedioate
  • Carbon
  • 1,6-Heptadien-4-ol,4-methyl-
  • DL-Mevalonolactone
  • 7-O-[hydrogen (3S)-3-hydroxy-3-methylglutaryl]retronecanol
  • 4-Hydroxy-4-methyldihydro-2H-pyran-2,6(3H)-dione
  • 4-methyl-4-trimethylsilyloxyoxane-2,6-dione
  • diethyl 3-hydroxy-3-methylglutarate

DownStream

  • 9,10-Anthracenedione,1,4,5-trihydroxy-2-methyl-
  • 4-Hydroxy-4-methyldihydro-2H-pyran-2,6(3H)-dione
  • 1,3-Dicyclohexylurea
  • Chrysophanic acid
  • D-Mevalonolactone
  • 3-ACETOXY-3-METHYLPENTANE-1,5-DIOIC ACID ANHYDRIDE
  • 3-Methylpentane-1,3,5-triol
  • DL-Mevalonolactone
  • diethyl 3-hydroxy-3-methylglutarate
  • 3,5-Dihydroxy-3-Methylpentanoic Acid

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.

NMR Biomed. 19(2) , 271-8, (2006)

A diagnosis of 3-methylglutaconic aciduria type I (OMIM: 250950) based on elevated urinary excretion of 3-methylglutaconic acid (3MGA), 3-methylglutaric acid (3MG) and 3-hydroxyisovaleric acid (3HIVA)...

Unimolecular reaction chemistry of a charge-tagged beta-hydroxyperoxyl radical.

Phys. Chem. Chem. Phys. 16(45) , 24954-64, (2014)

β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They are intermediates in the combustion of alcohols. In these environment...

Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.

J. Child Neurol. 16(2) , 136-8, (2001)

We report a patient with mitochondrial DNA depletion, partial complex II and IV deficiencies, and 3-methylglutaconic aciduria. Complex II deficiency has not been previously observed in mitochondrial D...


More Articles

Related Compounds

  • 3-hydroxy-3-methylglutaric acid
  • 3-hydroxy-3-methylglutaric acid dimethyl ester
  • 3-hydroxy-3-methylglutaric acid monomethyl ester
  • 3-Hydroxy-3-methylglutaric acid hydrogen 1-(2,3,15,19,23,27,31-heptahydroxy-3,7,11,15,19,23,27,31,35-nonamethyl-6,10,34-hexatriacontatrien-1-yl) ester
  • 3-Hydroxy-3-(2H3)methylpentanedioic acid
  • 3-Hydroxy-3-methylcyclobutanecarboxylic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • Ethyl (S)-2-amino-5,5,5-trifluoropentanoate
  • 4-Fluoro-3-methylbut-1-yne
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine