Chaetoglobosin A

Suppliers

Names

[ Name ]:
Chaetoglobosin A

[Synonym ]:
chaetoglobosins
Chaetoglobosin A
CHAETOGLOBOSIN A
CHAETOGLOBOSIN
CHAETOGLOBOSINB
18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1
CHAETOGLOBOSINE
(13)cytochalasa-13,17,21-triene-1,20,23-trione,6,7-epoxy-19-hydroxy-10-(1h-ind
CHAETOGLOBOSINM
CHAETOGLOBOSINL

Chemical & Physical Properties

[ Density]:
1.3 g/cm3

[ Boiling Point ]:
789.7ºC at 760 mmHg

[ Molecular Formula ]:
C₃₂H₃₆N₂O₅

[ Molecular Weight ]:
528.63900

[ Flash Point ]:
431.4ºC

[ Exact Mass ]:
528.26200

[ PSA ]:
111.79000

[ LogP ]:
4.16120

[ Index of Refraction ]:
1.651

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5305000

CHEMICAL NAME :: (13)Cytochalasa-13,17,21-triene-1,20,23-trione, 6,7-epoxy-19-hydroxy-10-(1H-indol-3-yl)- 16,18-dimethyl-, (7S,13E,16S,17E,19R,21E)-

CAS REGISTRY NUMBER :: 50335-03-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C32-H36-N2-O5

MOLECULAR WEIGHT :: 528.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Liver - other changes

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 700 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: MAIKD3 Maikotokishin (Tokyo). Mycotoxin. (Maikotokishin Kenkyukai, c/o Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku, Tokyo 162, Japan) No.1- 1975- Volume(issue)/page/year: (10),17,1980

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach.

Biochim. Biophys. Acta 1846(2) , 599-616, (2014)

Although cytoskeletal-directed agents have been a mainstay in chemotherapeutic protocols due to their ability to readily interfere with the rapid mitotic progression of neoplastic cells, they are all ...

Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells.

Cancer Lett. 356(2 Pt B) , 418-33, (2015)

Adverse side effects and acquired resistance to conventional platinum based chemotherapy have become major impediments in ovarian cancer treatment, and drive the development of more selective anticanc...

Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway.

Immunobiology 218(3) , 292-302, (2013)

Chaetoglobosin F (Cha F), a cytochalasan-based alkaloid, was obtained from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E019. Dendritic cells (DCs), the most potent antigen presenti...

Camellianin A
lactococcin A
maquiroside A
actinoplanone A
Influenza A virus-IN-4
S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (4E,7E,10E,13E,16E)-icosa-4,7,10,13,16-pentaenethioa
N-(2,4-dimethylphenyl)-2,4-dioxo-1-phenylpyrrolidine-3-carboxamide
4-(Pyrimidin-2-yl)pyrrolidin-2-one
(1S,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 6-nitro-2-oxo-2H-chromene-3-carboxylate
(E)-2-((4-ethoxy-3-methoxybenzylidene)amino)-3a,4,5,6,7,7a-hexahydrobenzo[b]thiophene-3-carbonitrile
5-(4-ethylphenyl)-2-(pyridin-3-yl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazine
2-(pyridin-3-yl)-5-(p-tolyl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazine
(E)-N-ethyl-N-(2-hydroxy-3-(3-((hydroxyimino)methyl)-1H-indol-1-yl)propyl)-4-methylbenzenesulfonamide
{2-Hydroxy-3-[3-((hydroxyimino)methyl)indolyl]propyl}(methylsulfonyl)(2,4,6-tr imethylphenyl)amine
1-[3-(2,6-dimethylpiperidin-1-yl)-2-hydroxypropyl]-1H-indole-3-carbaldehyde oxime
tert-Butyl (1-(3-nitrophenyl)allyl) carbonate

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.