8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

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Names

[ CAS No. ]:
5053-14-5

[ Name ]:
8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[Synonym ]:
8-benzyl-1-oxa-2-oxo-3,8-diazospiro<4,5>decane
8-benzyl-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
457.1ºC at 760 mmHg

[ Molecular Formula ]:
C14H18N2O2

[ Molecular Weight ]:
246.30500

[ Flash Point ]:
230.2ºC

[ Exact Mass ]:
246.13700

[ PSA ]:
45.06000

[ LogP ]:
1.33890

[ Index of Refraction ]:
1.6

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RO0220000
CHEMICAL NAME :
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-benzyl-
CAS REGISTRY NUMBER :
5053-14-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H18-N2-O2
MOLECULAR WEIGHT :
246.34
WISWESSER LINE NOTATION :
T6N CXTJ A1R& C-& DT5MVOX EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
319 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,185,1969

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Aminomethyl)-1-benzyl-4-piperidinol
  • 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetohydrazide
  • Triphosgene
  • 1-benzyl-4-cyano-4-hydroxypiperidine
  • N-Benzyl-4-piperidone
  • Ethyl carbonate
  • N,N-Carbonyldiimidazole

DownStream

  • 8-(3-Phenyl-1-propenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-(p-Aminophenethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 3-methyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one(SALTDATA: HCl)
  • 1-Oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
  • 8-(p-Ethoxyphenylcarbamoylmethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-[3,4-(Methylenebisoxy)phenethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 8-phenacyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one,hydrochloride
  • 8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-(Diphenylmethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-Methyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-Benzyl-1,8-diazaspiro[4.5]decan-2-one
  • 8-(2-phenoxyethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one,hydrochloride