D,L-Buthionine-(S,R)-sulfoximine

Names

[ Name ]:
D,L-Buthionine-(S,R)-sulfoximine

[Synonym ]:
2-amino-4-(butylsulfonimidoyl)butanoic acid
DL-Buthionine (S,R)-sulfoximine
EINECS 246-685-1
MFCD00070309
D,L-Buthionine-(S,R)-sulfoximine

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
382.3ºC at 760 mmHg

[ Melting Point ]:
215ºC (dec.)(lit.)

[ Molecular Formula ]:
C₈H₁₈N₂O₃S

[ Molecular Weight ]:
222.30500

[ Flash Point ]:
185ºC

[ Exact Mass ]:
222.10400

[ PSA ]:
112.62000

[ LogP ]:
2.30100

[ Index of Refraction ]:
1.537

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7713435

CHEMICAL NAME :: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-

CAS REGISTRY NUMBER :: 5072-26-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H18-N2-O3-S

MOLECULAR WEIGHT :: 222.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - other effects

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,133,1992

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
EK7713435

Articles

Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin

Exp. Cell Res. 323(1) , 77-86, (2014)

Matrix metalloproteinases (MMPs) play a critical role in inflammation and ulcerations in gut of Crohn׳s disease (CD) patients. Intestinal subepithelial myofibroblasts (ISEMFs) secrete MMPs in response...

Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise.

Exp. Biol. Med. (Maywood.) 239(4) , 394-403, (2014)

The glutathione couple GSH/GSSG is the most abundant cellular redox buffer and is not at equilibrium among intracellular compartments. Perturbation of glutathione poise has been associated with tumori...

Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.

Chem. Biol. Interact. 225 , 13-20, (2015)

Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury in...

D,L-buthionine-(S,R)-sulfoximine
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