Oleanic acid

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Names

[ CAS No. ]:
508-02-1

[ Name ]:
Oleanic acid

[Synonym ]:
oleanoic acid
Oleanol
CARYOPHYLLIN
Oleanic acid
3-beta-Hydroxyolean-12-en-28-oic acid
Oleanolicacid
Taraligenin
Guagenin
Araligenin
Oleanolic Acid Hydrate
MoMorgenin
MFCD00064914
Taragenin
Gledigeni
Oleanolic
Oleanolic Acid
EINECS 208-081-6

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
553.5±50.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C30H48O3

[ Molecular Weight ]:
456.700

[ Flash Point ]:
302.6±26.6 °C

[ Exact Mass ]:
456.360352

[ PSA ]:
57.53000

[ LogP ]:
9.06

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.557

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK0177965
CHEMICAL NAME :
Olean-12-en-28-oic acid, 3-hydroxy-, (3-beta)-
CAS REGISTRY NUMBER :
508-02-1
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C30-H48-O3
MOLECULAR WEIGHT :
456.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 44,456,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,450,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 44,456,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 44,456,1992

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
RK0177965

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • parkioside B
  • 3β-benzoyloxy-28-nor-oleana-12,17-diene
  • 18,28-cyclo-olean-12-en-3β-ol
  • Oleanolic acid benzoate
  • tert-butyl(((4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13-octadecahydro-4a,14b-methanopicen-10-yl)oxy)dimethylsilane

DownStream

  • Ethyl oleanolate
  • Crategolic acid
  • Methyl oleanolate
  • 2,7-Dimethylnaphthalene
  • tetramethylbenzene
  • Naphthalene, 1,2,7-trimethyl-
  • Lupane
  • 2,9-Dimethylpicene
  • Benzyl oleanolate
  • Methyl (3β)-3-acetoxy-12-oxooleanan-28-oate

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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J. Chromatogr. A. 1381 , 229-38, (2015)

Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mang...

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Plant Cell Physiol. 56 , 1172-82, (2015)

Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency ...

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Phytochemistry 108 , 157-70, (2014)

The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, tw...


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Related Compounds

  • 3-O-β-D-glucopyranosyl-(1-3)-O-α-L-arabinopyranoside of oleanic acid
  • Octanethioic acid S-propyl ester
  • Hexanethioic acid S-decyl ester
  • Thiopropionic acid S-undecyl ester
  • trisporic acid
  • Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
  • 5-(Morpholine-4-carbonyl)-2-thia-5-azabicyclo[2.2.1]heptane
  • Methyl 2-[4-(but-2-ynamido)phenyl]acetate
  • 2-(Difluoro(methoxy)methyl)pyrrolidine
  • 3-(3-chlorophenyl)-N-(4-methylidenecyclohexyl)propanamide
  • 2-[Methyl(pyrimidin-2-yl)amino]cyclobutan-1-ol
  • 3-Amino-4-(2,4,5-trifluorophenyl)butan-1-ol
  • 3-Ethynyl-3-hydroxy-1-methylindolin-2-one
  • 2-(4-Methylcyclohexyl)-4-nitroaniline
  • Tert-butyl (2-methylallyl)(phenyl)carbamate
  • 1-Methyl-N-(2-methylphenyl)-1H-pyrazol-4-amine
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