dopamine
Suppliers
Names
[ CAS No. ]:
51-61-6
[ Name ]:
dopamine
[Synonym ]:
3,4-Dihydroxy-b-phenethylamine Hydrochloride
4-(2-aminoethyl)benzene-1,2-diol
1,2-Benzenediol, 4-(2-aminoethyl)-
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-aminoéthyl)benzène-1,2-diol chlorhydrate
b-(3,4-Dihydroxyphenyl)ethylamine Hydrochloride
Tensamin
α-(3,4-Dihydroxyphenyl)-β-aminoethane
4-(2-Aminoethyl)benzene-1,2-diol hydrochloride (1:1)
Rascordin
Pyrocatechol, 4- (2-aminoethyl)-, hydrochloride
4-(2-aminoethyl)-pyrocatechol
EINECS 200-110-0
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1)
1,2-Benzenediol, 4- (2-aminoethyl)-, hydrochloride
4-(2-Aminoethyl)-1,2-benzenediol hydrochloride (1:1)
4-(2-aminoethyl)-Pyrocatechol hydrochloride
4-(2-Aminoethyl)benzol-1,2-diolhydrochlorid
.α.-(3,4-Dihydroxyphenyl)-.β.-aminoethane
4-(2-Aminoethyl)catechol, hydrochloride
β-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
DA
dopamine
a-(3,4-Dihydroxyphenyl)-b-aminoethane
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
337.7±27.0 °C at 760 mmHg
[ Melting Point ]:
218-220ºC
[ Molecular Formula ]:
C8H11NO2
[ Molecular Weight ]:
153.18
[ Flash Point ]:
158.0±23.7 °C
[ PSA ]:
66.48000
[ LogP ]:
0.12
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.619
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UX1088000
- CHEMICAL NAME :
- Pyrocatechol, 4-(2-aminoethyl)-
- CAS REGISTRY NUMBER :
- 51-61-6
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C8-H11-N-O2
- MOLECULAR WEIGHT :
- 153.20
- WISWESSER LINE NOTATION :
- Z2R CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 163 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory stimulation Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory stimulation Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracervical
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 74 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9 gm/kg/30D-C
- TOXIC EFFECTS :
- Blood - normocytic anemia Blood - changes in spleen Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10920 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 120 ug/kg
- SEX/DURATION :
- lactating female 2 hour(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 1-7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - other postnatal measures or effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 10-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 10-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 1-7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - other postnatal measures or effects
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,9,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3655 No. of Facilities: 50 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8422 (estimated) No. of Female Employees: 7695 (estimated)