Echinomycin
Suppliers
Names
Chemical & Physical Properties
[ Density]:
1.41 g/cm3
[ Boiling Point ]:
1427.2ºC at 760 mmHg
[ Molecular Formula ]:
C51H64N12O12S2
[ Molecular Weight ]:
1101.26000
[ Flash Point ]:
817ºC
[ Exact Mass ]:
1100.42000
[ PSA ]:
352.40000
[ LogP ]:
1.82630
[ Index of Refraction ]:
1.536
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JW5250000
- CHEMICAL NAME :
- Echinomycin
- CAS REGISTRY NUMBER :
- 512-64-1
- BEILSTEIN REFERENCE NO. :
- 0078671
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C51-H64-N12-O12-S2
- MOLECULAR WEIGHT :
- 1101.39
- WISWESSER LINE NOTATION :
- T C-16-6-16-/CE& A B C- C-- 2CP E& AS CX C-S DNV GMV KOV NNV PXNV TMV A&OV D&NVTJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 629 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 89 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - nausea or vomiting
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 27 umol/L
- REFERENCE :
- HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New series: V.1-49, 1935-78. For publisher information, see HEPHD2. Volume(issue)/page/year: 38(Pt 2),623,1975
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311 + H331-H361
[ Precautionary Statements ]:
P261-P280-P301 + P310-P311
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R46
[ Safety Phrases ]:
53-36/37/39-45
[ RIDADR ]:
UN 3462 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
JW5250000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
J. Reprod. Dev. 58(6) , 678-84, (2012)
Endothelin (ET)-2 plays a crucial role in ovarian ovulation in mammals. The present study was designed to test the hypothesis that hypoxia-inducible factor (HIF)-1α-mediated transcriptional activation...
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 7) , 660-4, (2009)
The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This comple...
Exp. Mol. Med. 44(10) , 615-21, (2012)
Echinomycin is a small-molecule inhibitor of hypoxia- inducible factor-1 DNA-binding activity, which plays a crucial role in ovarian ovulation in mammalians. The present study was designed to test the...