Echinomycin
Echinomycin structure
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Common Name | Echinomycin | ||
|---|---|---|---|---|
| CAS Number | 512-64-1 | Molecular Weight | 1101.26000 | |
| Density | 1.41 g/cm3 | Boiling Point | 1427.2ºC at 760 mmHg | |
| Molecular Formula | C51H64N12O12S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 817ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Regulatory effect of hypoxia-inducible factor-1α on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary.
J. Reprod. Dev. 58(6) , 678-84, (2012) Endothelin (ET)-2 plays a crucial role in ovarian ovulation in mammals. The present study was designed to test the hypothesis that hypoxia-inducible factor (HIF)-1α-mediated transcriptional activation contributes to the increased expression of ET-2 gene in re... |
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Interaction of an echinomycin-DNA complex with manganese ions.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 7) , 660-4, (2009) The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This complex crystallizes in a different space group compared with rel... |
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Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins.
Exp. Mol. Med. 44(10) , 615-21, (2012) Echinomycin is a small-molecule inhibitor of hypoxia- inducible factor-1 DNA-binding activity, which plays a crucial role in ovarian ovulation in mammalians. The present study was designed to test the hypothesis that hypoxia-inducible factor (HIF)-1α-mediated... |
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A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
Biochem. J. 446(1) , 159-63, (2012) MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regula... |
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Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Basic Clin Pharmacol Toxicol. 110(4) , 327-34, (2012) Up-regulation of vascular endothelial growth factor (VEGF) is important to hepatocyte regeneration in the late stages of acetaminophen (APAP) toxicity in the mouse. This study was conducted to examine the relationship of hypoxia-inducible factor 1α (HIF-1α) t... |
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Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.
J. Antibiot. 64(1) , 117-22, (2011) Quinomycin antibiotics, represented by echinomycin, are an important class of antitumor antibiotics. We have recently succeeded in identification of biosynthetic gene clusters of echinomycin and SW-163D, and have achieved heterologous production of echinomyci... |
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Drug release from a chemically-anchored PEG/phospholipid monolayer onto polymer-coated metallic stents.
J. Biomater. Sci. Polym. Ed. 21(6) , 789-802, (2010) We have prepared a covalently-grafted phsopholipid/PEG mixed monolayer onto drug-loaded polymercoated stainless-steel stents by in situ polymerization. To introduce a biocompatile surface on the stent surface, AcPC (1-palmitoyl-2-[12-(acryloyloxy)dodecanoyl]-... |
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Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model.
Injury 44(4) , 570-5, (2013) Heterotopic ossification (HO) frequently causes complications following orthopaedic and trauma surgery and may drastically reduce the postoperative outcome due to pain and joint contracture. Current therapeutic options include NSAID's and local radiation. How... |
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Antitumour drug-DNA interactions: NMR studies of echinomycin and chromomycin complexes.
Q. Rev. Biophys. 22(2) , 93-138, (1989)
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In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan.
PLoS ONE 8(2) , e56772, (2013) Quinoxaline-2-carboxylic acid (QXC) and 3-hydroxyquinaldic acid (HQA) feature in quinomycin family and confer anticancer activity. In light of the significant potency against cancer, the biosynthetic gene clusters have been reported from many different Strept... |