Methylene-bis(4-cyclohexylisocyanate)

Suppliers

Names

[ Name ]:
Methylene-bis(4-cyclohexylisocyanate)

[Synonym ]:
Methylene-bis(4-cyclohexylisocyanate)
4,4'-Methylenebis(cyclohexyl isocyanate)
Dicyclohexylmethane 4,4′-diisocyanate
MFCD00015405
Dicyclohexylmethane 4,4'-Diisocyanate
4,4-Methylenebis(Cyclohexyl Isocyanate)
EINECS 225-863-2

Chemical & Physical Properties

[ Density]:
1.066 g/mL at 25 °C(lit.)

[ Boiling Point ]:
168 °C / 1.5mmHg

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C₁₅H₂₂N₂O₂

[ Molecular Weight ]:
262.34700

[ Flash Point ]:
211 ºC

[ Exact Mass ]:
262.16800

[ PSA ]:
58.86000

[ LogP ]:
3.16570

[ Index of Refraction ]:
n20/D 1.497(lit.)

[ Water Solubility ]:
Insoluble/Reactive

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ9250000

CHEMICAL NAME :: Isocyanic acid, methylenedi-4,1-cyclohexylene ester

CAS REGISTRY NUMBER :: 5124-30-1

LAST UPDATED :: 199806

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C15-H22-N2-O2

MOLECULAR WEIGHT :: 262.39

WISWESSER LINE NOTATION :: L6TJ ANCO D1- AL6TJ DNCO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530188

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9900 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS000555173

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 ppm/5H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,998,1991

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle weakness

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 51 mg/m3/1H

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534736 *** REVIEWS *** ACGIH TLV-TWA 0.054 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.054 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.054 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 ppm (0.11 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE-air:CL 0.01 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1655 No. of Facilities: 102 (estimated) No. of Industries: 6 No. of Occupations: 22 No. of Employees: 4022 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1175 No. of Facilities: 624 (estimated) No. of Industries: 16 No. of Occupations: 18 No. of Employees: 7764 (estimated) No. of Female Employees: 637 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H319-H331-H334-H335

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340 + P312-P342 + P311-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23;R36/37/38;R42/43

[ Safety Phrases ]:
S26-S28-S38-S45-S1/2

[ RIDADR ]:
UN 2206 6.1/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
NQ9250000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Bis(4-aminocyclohexyl)methane
Urea
4,4'-methylene-di(cyclohexylcarbamate) dimethyl ester
Carbamic acid, N,N'-methylenebis(4,1-cyclohexanediyl)bis-, C,C'-dibutyl ester
phosgene
4-methylphenyl 2,4-dinitrophenyl carbonate
N,N'-(4,4'-methanediyl-dicyclohexyl)-di(carbamic acid (2,4,6-trimethylphenyl) ester)

DownStream

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