Dimidium bromide

Suppliers

Names

[ CAS No. ]:
518-67-2

[ Name ]:
Dimidium bromide

[Synonym ]:
Dimidiniumbromide
Phenanthridinium1553
DiMidiuM BroMide
DIMIDIUM BROMIDE 1/2 H2O
Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide (1:1)
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide Trypadine
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide
3,8-diamino-5-methyl-6-phenyl-phenanthridinium,bromide
MFCD00011757
Phenanthridiniumcompound1553
6c46
EINECS 208-256-7
TRYPADINE

Chemical & Physical Properties

[ Melting Point ]:
243-248 °C(lit.)

[ Molecular Formula ]:
C20H18BrN3

[ Molecular Weight ]:
380.281

[ Exact Mass ]:
379.068390

[ PSA ]:
55.92000

[ LogP ]:
1.81530

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SF7960500
CHEMICAL NAME :
Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide
CAS REGISTRY NUMBER :
518-67-2
LAST UPDATED :
199512
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H18-N3.Br
MOLECULAR WEIGHT :
380.32
WISWESSER LINE NOTATION :
T B666 HKJ EZ H1 IR& LZ &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 5,261,1950 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10 mg/kg/5D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6236 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 67 (estimated) No. of Female Employees: 34 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
SF7960500

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-butoxy-5-methyl-6-phenyl-5,6-dihydro-phenanthridine-3,8-diyldiamine

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy.

Int. J. Biochem. 14 , 493, (1982)

1. The absorption spectrum of three phenanthridine drugs (ethidium, dimidium and prothidium bromide) bound to natural DNAs of differing G-C content were obtained using a novel mixing scheme and analys...

[Effect of some DNA-intercalators and antioxidants on the phagosome- lysosome fusion and F-actin content in murine peritoneal macrophages].

Tsitologiia 40(6) , 585-90, (1998)

Effect of DNA-intercalators ethidium bromide (EB, 0.005 and 0.015 mM) and dimidium bromide (DB, 0.005 and 0.010 mM) and antioxidative compounds acetylsalicylic acid (ASA, 0.05 and 0.50 mM) and beta-ca...

[The toxicity of sanguinarine compared to a number of other DNA-tropic compounds for ethidium bromide-sensitive and -resistant transformed murine fibroblasts in culture].

Tsitologiia 31(11) , 1363-8, (1989)

A natural DNA-intercalator plant benzo-c-phenanthridine alkaloid sanguinarine is more toxic for mouse transformed fibroblast L-cells in culture than synthetic DNA-intercalator ethidium bromide (EtB) a...


More Articles

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