Nimesulide

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Names

[ CAS No. ]:
51803-78-2

[ Name ]:
Nimesulide

[Synonym ]:
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide Nimesulide
EINECS 257-431-4
AULIN
N-(2-phenoxy-4-nitrophenyl)methanesulfonamide
Nimepast
Mesulid
Flogovital
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-
Sulidene
Antifloxil
Nimed
4-nitro-2-phenoxymethanesulfonanilide
Nisulid
Guaxan
R-805
Nimesulide
N-(4-Nitro-2-phenoxy-phenyl)-methanesulfonamide
MFCD00079470

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
442.0±55.0 °C at 760 mmHg

[ Melting Point ]:
140-146°C

[ Molecular Formula ]:
C13H12N2O5S

[ Molecular Weight ]:
308.310

[ Flash Point ]:
221.1±31.5 °C

[ Exact Mass ]:
308.046692

[ PSA ]:
109.60000

[ LogP ]:
3.79

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB0970000
CHEMICAL NAME :
Methanesulfonanilide, 4'-nitro-2'-phenoxy-
CAS REGISTRY NUMBER :
51803-78-2
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C13-H12-N2-O5-S
MOLECULAR WEIGHT :
308.33
WISWESSER LINE NOTATION :
WS1&MR BOR& DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 34,759,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
392 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
216 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
PB0970000

[ Packaging Group ]:
III

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2'-Phenoxymethanesulfonanilide

DownStream

  • Propyl paraben
  • Phenacetin
  • 4-Nitro-2-phenoxyaniline
  • Methyl 4-hydroxybenzoate
  • 4-Hydroxybenzoic acid
  • N-(4-Amino-2-phenoxyphenyl)methanesulfonamide
  • 4-HYDROXY NIMESULIDE

Articles

Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.

J. Pharm. Biomed. Anal. 106 , 61-70, (2015)

An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic gro...

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk.

Sci. Total Environ. 508 , 240-50, (2015)

The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples cover...

Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.

J. Phys. Chem. B 118(33) , 9974-82, (2014)

Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly i...


More Articles

Related Compounds

  • Nimesulide D5
  • 4-HYDROXY NIMESULIDE
  • Nimesulide Impurity 3
  • 4’-Hydroxy nimesulide-d4
  • N-Methylsulfonyl Nimesulide
  • AMino NiMesulide NAC Adduct SodiuM Salt
  • 3-(pyrrolidin-3-yl)benzo[d]oxazol-2(3H)-one hydrochloride
  • 3-Morpholin-4-yl-5-nitro-benzamide
  • (1R,2R,6S,7S,8R,11S,15S)-2,7,11-trihydroxy-2,6,8,10,10-pentamethyl-15-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-14-azabicyclo[11.3.1]heptadec-13-en-9-one
  • Methyl 4-(aminomethyl)-5-methyl-2-furoate
  • 7-Chloro-2-methyl-2,3-dihydrobenzofuran-5-carboxylic acid
  • 3-Chloro-6-methyl-2-(1E)-1-propen-1-ylphenol
  • 6-(Azetidin-1-ylsulfonyl)nicotinonitrile
  • 2-[4'-(Trifluromethyl)phenyl]-4-methylimidazole-5-methanol
  • 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethan-1-one hydrobromide
  • N-(3,4-difluorophenyl)-4-hydroxy-2-oxo-1-(prop-2-en-1-yl)-1,2-dihydroquinoline-3-carboxamide
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