Nimesulide

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Names

[ CAS No. ]:
51803-78-2

[ Name ]:
Nimesulide

[Synonym ]:
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide Nimesulide
EINECS 257-431-4
AULIN
N-(2-phenoxy-4-nitrophenyl)methanesulfonamide
Nimepast
Mesulid
Flogovital
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-
Sulidene
Antifloxil
Nimed
4-nitro-2-phenoxymethanesulfonanilide
Nisulid
Guaxan
R-805
Nimesulide
N-(4-Nitro-2-phenoxy-phenyl)-methanesulfonamide
MFCD00079470

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
442.0±55.0 °C at 760 mmHg

[ Melting Point ]:
140-146°C

[ Molecular Formula ]:
C13H12N2O5S

[ Molecular Weight ]:
308.310

[ Flash Point ]:
221.1±31.5 °C

[ Exact Mass ]:
308.046692

[ PSA ]:
109.60000

[ LogP ]:
3.79

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB0970000
CHEMICAL NAME :
Methanesulfonanilide, 4'-nitro-2'-phenoxy-
CAS REGISTRY NUMBER :
51803-78-2
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C13-H12-N2-O5-S
MOLECULAR WEIGHT :
308.33
WISWESSER LINE NOTATION :
WS1&MR BOR& DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 34,759,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
392 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
216 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,1254,1975

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
PB0970000

[ Packaging Group ]:
III

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2'-Phenoxymethanesulfonanilide

DownStream

  • Propyl paraben
  • Phenacetin
  • 4-Nitro-2-phenoxyaniline
  • Methyl 4-hydroxybenzoate
  • 4-Hydroxybenzoic acid
  • N-(4-Amino-2-phenoxyphenyl)methanesulfonamide
  • 4-HYDROXY NIMESULIDE

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