Nimesulide
Nimesulide structure
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Common Name | Nimesulide | ||
|---|---|---|---|---|
| CAS Number | 51803-78-2 | Molecular Weight | 308.310 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 442.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C13H12N2O5S | Melting Point | 140-146°C | |
| MSDS | Chinese USA | Flash Point | 221.1±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.
J. Pharm. Biomed. Anal. 106 , 61-70, (2015) An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction ... |
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Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk.
Sci. Total Environ. 508 , 240-50, (2015) The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in orde... |
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Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.
J. Phys. Chem. B 118(33) , 9974-82, (2014) Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand t... |
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Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner.
Arthritis. Res. Ther. 17 , 321, (2015) The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to determine the influence of N-acylethanolamines anandam... |
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Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.
Sci. Total Environ. 511 , 153-60, (2015) The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using pulverised liquid extraction (PuLE), solid phase extractio... |
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Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice.
J. Ethnopharmacol. 172 , 273-80, (2015) Yulangsan polysaccharide (YLSPS) is often used in popular folk medicine in the Guangxi Zhuang Autonomous Region of China as a chief ingredient of Millettia pulchra, which is used as a hepatic protection, anti-aging and memory improving agent.This study was de... |
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Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.
Cytometry. A 83(4) , 403-8, (2013) Idiosyncratic drug-induced hepatotoxicity accounts for about 13% of all cases of acute liver failure, therefore cited as the most frequent reason for post-marketing drug withdrawal. Despite this, the underlying mechanisms remain poorly understood due to lack ... |
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Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia.
Inflammopharmacology 23 , 173-85, (2015) Quercetin, a major flavonol, present abundantly in apples and onions, is widely studied for ameliorating metabolic syndrome abnormalities. However, quercetin is mainly present in plant food in the form of quercetin glycosides and has been reported for poor ga... |
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Motor learning in common marmosets: Vestibulo-ocular reflex adaptation and its sensitivity to inhibitors of Purkinje cell long-term depression
Neurosci. Res. 83 , 33-42, (2014) • We developed an eye movement measuring system for marmosets. • We developed a protocol of adaptation of vestibulo-ocular reflex for marmosets. • T-588, a blocker of cerebellar LTD, blocks vestibulo-ocular reflex adaptation. • Nimesulide, a blocker of LTD, a... |
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Sulfation of melatonin: enzymatic characterization, differences of organs, species and genders, and bioactivity variation.
Biochem. Pharmacol. 94(4) , 282-96, (2015) Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes. In metabolism pathways of Mel, 6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the most abundant metabolites account for over 90% of total Mel... |