Kaempferol

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Names

[ CAS No. ]:
520-18-3

[ Name ]:
Kaempferol

[Synonym ]:
3,4',5,7-Tetrahydroxyflavone Hydrate
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2- (4-hydroxyphenyl)-
Pelargidenolon
EINECS 208-287-6
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-
campherol
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
KaeMpferol Hydrate
MFCD00016938
Swartziol
asurone
3,5,7,4'-tetrahydroxyflavone
nimbecetin
Trifolitin
Populnetin
3 4' 5 7-tetrahydroxyflavone
5,7,4'-trihydroxyflavonol
kampherol
Kaempferol
Rhamnolutin
Robigenin
Swartsiol
Rhamnolutein
3,4',5,7-tetrahydroxyflavone
3,4,5,7-Tetrahydroxyflavone
kempferol

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
582.1±50.0 °C at 760 mmHg

[ Melting Point ]:
276°C

[ Molecular Formula ]:
C15H10O6

[ Molecular Weight ]:
286.236

[ Flash Point ]:
226.1±23.6 °C

[ Exact Mass ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.785

[ Storage condition ]:
−20°C

[ Water Solubility ]:
ethanol: 20 mg/mL

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK9275200
CHEMICAL NAME :
Flavone, 3,4',5,7-tetrahydroxy-
CAS REGISTRY NUMBER :
520-18-3
BEILSTEIN REFERENCE NO. :
0304401
LAST UPDATED :
199612
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C15-H10-O6
MOLECULAR WEIGHT :
286.25
WISWESSER LINE NOTATION :
T66 BO EVJ CR DQ& DQ GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,45,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,171,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,171,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H341

[ Precautionary Statements ]:
P281-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
-

[ RTECS ]:
LK9275200

[ HS Code ]:
2914501900

Synthetic Route

Precursor & DownStream

Precursor

  • 3,5,7,4''-TETRAHYDROXYFLAVANONE
  • Astragalin
  • 5,7-BIS-(BENZYLOXY)-2-(4-(BENZYLOXY)PHENYL)-3-HYDROXY-4H-CHROMEN-4-ONE
  • Flavone, 3-hydroxy-4',5,7-trimethoxy-
  • Aromadendrin
  • Afzelin
  • Kaempferol-3-beta-O-glucuronide

DownStream

  • Isokaempferide
  • Kaempferide
  • 2,4,6-Trihydroxybenzaldehyde
  • 4-Hydroxybenzoic acid
  • Kaempferitrin
  • 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
  • Astragalin
  • [4-(3,5,7-trihydroxy-4-oxochromen-2-yl)phenyl] hydrogen sulfate
  • Phloroglucinol
  • 2,4-Dinitrophenol

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Antiviral effect of methylated flavonol isorhamnetin against influenza.

PLoS ONE 10(3) , e0121610, (2015)

Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc...

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts.

Biochem. Pharmacol. 96 , 337-48, (2015)

During senescence, cells express molecules called senescence-associated secretory phenotype (SASP), including growth factors, proinflammatory cytokines, chemokines, and proteases. The SASP induces a c...

Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation.

J. Nat. Med. 69 , 340-8, (2015)

The restoration of the epidermal epithelium through re-epithelialization is a critical process in wound healing. Directed keratinocyte migration to the wound is required, and the retardation of this p...


More Articles


Related Compounds

  • kaempferol 3,7
  • kaempferol-3-O-
  • 7-Methylkaempferol
  • 3-Methylkaempferol
  • 4'-Methylkaempferol
  • 4'-Methylkaempferol
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)thiophene-2-sulfonamide
  • (E)-N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-2-phenylethenesulfonamide
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-1-(m-tolyl)methanesulfonamide
  • 5-chloro-N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)thiophene-2-sulfonamide
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-4-methoxy-2-methylbenzenesulfonamide
  • 3-fluoro-N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-4-methoxybenzenesulfonamide
  • N-(4-(N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)sulfamoyl)phenyl)acetamide
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-2-(4-methoxyphenyl)ethanesulfonamide
  • N-(2-(5-(furan-3-yl)thiophen-2-yl)ethyl)-2,5-dimethoxybenzenesulfonamide
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