Apigenin

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Names

[ CAS No. ]:
520-36-5

[ Name ]:
Apigenin

[Synonym ]:
5,7,4'-trihydroxyflavone
apigenol
Versuline
Versulin
4',5,7-Trihydroxyflavone
CHAMOMILE
Celery seed extract
C.I. NATURAL YELLOW 1
T66 BO EVJ CR DQ& GQ IQ
Apigenine
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Apigenin
EINECS 208-292-3
Pelargidenone
MFCD00006831

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
555.5±50.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₅

[ Molecular Weight ]:
270.237

[ Flash Point ]:
217.1±23.6 °C

[ Exact Mass ]:
270.052826

[ PSA ]:
90.90000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.732

[ Water Solubility ]:
DMSO: 27 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9276000

CHEMICAL NAME :: Flavone, 4',5,7-trihydroxy-

CAS REGISTRY NUMBER :: 520-36-5

BEILSTEIN REFERENCE NO. :: 0262620

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H10-O5

MOLECULAR WEIGHT :: 270.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR DQ& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LK9276000

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

Naringenin
Trimethylapigenin
ETHANONE, 2-CHLORO-1-(2,4,6-TRIHYDROXYPHENYL)-
4-hydroxybenzaldehyde
Cosmosiin
Phloroglucinol
7-O-α-L-rhamnopyranosyl-4'-O-rutinosylapigenin
4-iodo-1,3,5-trihydroxybenzene
4-(5-tributylstannyl-1,2-oxazol-3-ylidene)cyclohexa-2,5-dien-1-one

DownStream

Flavokawain A
Luteolin
Acacetin
7,4'-Di-O-methylapigenin
Genkwanin
Naringenin
4-Hydroxyacetophenone
Phloroglucinol
4-Hydroxybenzoic acid
5,7-BIS-(BENZYLOXY)-2-(4-(BENZYLOXY)PHENYL)-4H-CHROMEN-4-ONE

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts.

Biochem. Pharmacol. 96 , 337-48, (2015)

During senescence, cells express molecules called senescence-associated secretory phenotype (SASP), including growth factors, proinflammatory cytokines, chemokines, and proteases. The SASP induces a c...

Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells.

Mol. Med. Report. 12 , 2977-84, (2015)

Phytoestrogens have been demonstrated to inhibit tumor induction; however, their molecular mechanisms of action have remained elusive. The present study aimed to investigate the effects of a phytoestr...