O-Desmethylnaproxen

Suppliers

Names

[ CAS No. ]:
52079-10-4

[ Name ]:
O-Desmethylnaproxen

[Synonym ]:
(2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid

Chemical & Physical Properties

[ Boiling Point ]:
444.1ºC at 760mmHg

[ Melting Point ]:
182-183ºC

[ Molecular Formula ]:
C₁₃H₁₂O₃

[ Molecular Weight ]:
216.23300

[ Flash Point ]:
236.5ºC

[ Exact Mass ]:
216.07900

[ PSA ]:
57.53000

[ LogP ]:
2.73350

[ Appearance of Characters ]:
white

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H400

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-43-50/53

[ Safety Phrases ]:
36/37-60-61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(6-Methoxynaphthalen-2-yl)propanoic acid
Naproxen
2-(6-Methoxynaphthalen-2-yl)acetic acid

DownStream

2-(6-Methoxynaphthalen-2-yl)propanoic acid
(S)-Naproxen Methyl Ester

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

The pharmacokinetic profile of naproxen suppository in man.

Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2....

Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.

Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)

Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o...

High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.

J. Chromatogr. A. 383(2) , 449-55, (1986)

(Rac)-O-Desmethylnaproxen-d3
o-Nitrobenzyl-5 tetrahydro-5,6,7,7a 4H-thieno(3,2-c)pyridinone-2 oxala te [French]
O-(OCTYLPHOSPHORYL)CHOLINE SOLUTION
o-(3-Amino-4-sodiooxybenzoyl)benzoic acid sodium salt
O-Desmethyl apixaban
O-(2-phenylmethoxyethyl)hydroxylamine
2-(2-Methylphenoxy)-1-[5-(6-methylpyrimidin-4-yl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]ethan-1-one
3,5-dimethyl-6-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]-3H,4H-thieno[2,3-d]pyrimidin-4-one
4-[5-(3,4-Dimethoxybenzenesulfonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]-6-methylpyrimidine
3-Amino-2-(dimethyl-1,3-oxazol-2-yl)propan-1-ol
N-{2-[5-(furan-2-yl)thiophen-2-yl]ethyl}-1-methyl-1H-imidazole-4-sulfonamide
N-{2-[5-(furan-2-yl)thiophen-2-yl]ethyl}-N'-[(thiophen-2-yl)methyl]ethanediamide
(2S)-4-amino-1-(methylsulfanyl)butan-2-ol
N-(4-ethoxyphenyl)-6,7-dimethyl-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridine-2-carboxamide
2-Azido-4-(dimethylamino)butan-1-ol
4-cyano-N-{2-[5-(furan-2-yl)thiophen-2-yl]ethyl}benzene-1-sulfonamide

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