Physcion

Suppliers

Names

[ CAS No. ]:
521-61-9

[ Name ]:
Physcion

[Synonym ]:
1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Emodin 3-methyl ether
EINECS 208-315-7
MFCD00017374
Emodin monomethyl ether
9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-
Parietin
Methoxyemodin
1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
Emodin-3-methyl ether
Rheochrysidin
physicion
phycion
1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone
Physcion
1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether
1,8-Dihydroxy-3-methoxy-6-methylanthraquinone
1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone
Physcione

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
560.5±50.0 °C at 760 mmHg

[ Melting Point ]:
196-206°C

[ Molecular Formula ]:
C₁₆H₁₂O₅

[ Molecular Weight ]:
284.26

[ Flash Point ]:
215.4±23.6 °C

[ Exact Mass ]:
284.068481

[ PSA ]:
83.83000

[ LogP ]:
5.20

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.678

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6720000

CHEMICAL NAME :: Anthraquinone, 1,8-dihydroxy-3-methoxy-6-methyl-

CAS REGISTRY NUMBER :: 521-61-9

BEILSTEIN REFERENCE NO. :: 1915778

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H12-O5

MOLECULAR WEIGHT :: 284.28

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ FO1 LO1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CB6720000

[ HS Code ]:
2914699010

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Emodin
Dimethyl sulfate
methyl iodide
3,4-Dihydro-3,8,9-trihydroxy-3-methyl-6-methoxyanthracene-1(2H)-one
1-hydroxy-6,8-dimethoxy-3-methylanthracene-9,10-dione
Physcion-10,10'-bianthrone
1,4-Naphthalenedione,5-hydroxy-7-methyl-
1,8-dihydroxy-6-methoxy-3-methyl-10H-anthracen-9-one
2-Chloro-8-hydroxy-6-methoxy-1,4-naphthoquinone

DownStream

(8-acetyloxy-6-methoxy-3-methyl-9,10-dioxoanthracen-1-yl) acetate
2-METHYLANTHRACENE
Emodin
methyl iodide
1,8-dihydroxy-6-methoxy-3-methyl-10H-anthracen-9-one

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015)

Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two ...

Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008)

As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin deriva...

Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats.

Chem. Res. Toxicol. 28 , 1120-32, (2015)

Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. The...

Physcion-d3
Physcionanthron
diacetyl physcion
physcion bianthrone
physcion diglucoside
physcion 8-O-glucoside
2-Methyl-2-(trifluoromethyl)-1,3-propanediol
9-[3-(4,6-Diphenyl-1,3,5-triazin-2-yl)phenyl]-1,3-diphenylcarbazole
1,3-diphenyl-6-(9-phenylcarbazol-3-yl)-9H-carbazole
2,7-Dichloro-1H-benzo[d]imidazole-6-carboxylic acid
3-Bromo-2-fluoro-4-pyridineacetonitrile
tert-butyl 2-{2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetate
1H-Isoindole-1,3(2H)-dione,4,7-dibromo-2-(2-hexyldecyl)-
4-methanesulfonyl-N,2-dimethylaniline
3-Fluoro-4,5-dimethoxy-2-ureido-benzamide
2,4,5-Trichloro-6,7-dimethoxyquinazoline

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