CGP 57380

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
541.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₉FN₆

[ Molecular Weight ]:
244.228

[ Flash Point ]:
281.4±30.1 °C

[ Exact Mass ]:
244.087280

[ PSA ]:
92.51000

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.809

[ Storage condition ]:
-20℃

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.

Oncotarget 5(17) , 7691-704, (2014)

Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As CDK9 and Mnks play pivotal roles in the regulation of RNA transcription and protein synthesis, respectiv...

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.

Nat. Commun. 5 , 5413, (2014)

The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the M...

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

Cancer Lett. 357(2) , 612-23, (2015)

The Ras/Raf/MAPK and PI3K/Akt/mTORC1 cascades are two most aberrantly regulated pathways in cancers. As MAPK-interacting kinases (Mnks) are part of the convergent node of these two pathways, and play ...

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