CGP 57380
CGP 57380 structure
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Common Name | CGP 57380 | ||
|---|---|---|---|---|
| CAS Number | 522629-08-9 | Molecular Weight | 244.228 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 541.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C11H9FN6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 281.4±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.
Oncotarget 5(17) , 7691-704, (2014) Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As CDK9 and Mnks play pivotal roles in the regulation of RNA transcription and protein synthesis, respectively, they are important targets for drug development. We he... |
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MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Nat. Commun. 5 , 5413, (2014) The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and ... |
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Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.
Cancer Lett. 357(2) , 612-23, (2015) The Ras/Raf/MAPK and PI3K/Akt/mTORC1 cascades are two most aberrantly regulated pathways in cancers. As MAPK-interacting kinases (Mnks) are part of the convergent node of these two pathways, and play a pivotal role in cellular transformation, targeting Mnks h... |
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MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
EMBO J. 16 , 1921-1933, (1997) We have developed a novel expression screening method for identifying protein kinase substrates. In this method, a lambda phage cDNA expression library is screened by in situ, solid-phase phosphorylation using purified protein kinase and [gamma-32P]ATP. Scree... |
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Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.
Mol. Cell. Biol. 21 , 5500-5511, (2001) Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) an... |
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Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny.
Cancer Res. 66 , 1282-1288, (2006) The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy... |
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4E-BP restrains eIF4E phosphorylation.
Translation (Austin) 1 , e25819, (2016) In eukaryotes, mRNA translation is dependent on the cap-binding protein eIF4E. Through its simultaneous interaction with the mRNA cap structure and with the ribosome-associated eIF4G adaptor protein, eIF4E physically posits the ribosome at the 5' extremity of... |
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Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer.
Mol. Cancer Res. 14 , 216-27, (2016) Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells grown in collagen exhibit increased activation of the MAPK-interacting protein kinases (MNK) that me... |
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Inflammatory signaling compromises cell responses to interferon alpha.
Oncogene 31 , 161-72, (2012) Interferon alpha (IFNα) is widely used for treatment of melanoma and certain other malignancies. This cytokine as well as the related IFNβ exerts potent anti-tumorigenic effects; however, their efficacy in patients is often suboptimal. Here, we report that in... |