RICININE

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Names

[ CAS No. ]:
524-40-3

[ Name ]:
RICININE

[Synonym ]:
Recinine
4-methoxy-1-methyl-2-oxopyridine-3-carbonitrile
Ritsinin
4-Methoxy-1-methyl-2-oxo-1,2-dihydro-pyridin-3-carbonitril
4-methoxy-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
RICININE
Ricidine
Ricinin
Recinine Ricidine Ricinin Ritsinin

Chemical & Physical Properties

[ Density]:
1.23 g/cm3

[ Boiling Point ]:
370.9ºC at 760 mmHg

[ Melting Point ]:
200-201ºC

[ Molecular Formula ]:
C₈H₈N₂O₂

[ Molecular Weight ]:
164.16

[ Flash Point ]:
178.1ºC

[ Exact Mass ]:
164.05900

[ PSA ]:
55.02000

[ LogP ]:
0.26558

[ Index of Refraction ]:
1.547

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT3100000

CHEMICAL NAME :: Nicotinonitrile, 1,2-dihydro-4-methoxy-1-methyl-2-oxo-

CAS REGISTRY NUMBER :: 524-40-3

BEILSTEIN REFERENCE NO. :: 0139222

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-N2-O2

MOLECULAR WEIGHT :: 164.18

WISWESSER LINE NOTATION :: T6NVJ A1 CCN DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,23,1953

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ Hazard Codes ]:
T,Xn,F

[ Risk Phrases ]:
25-36-20/21/22-11

[ Safety Phrases ]:
45-36/37-16

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
QT3100000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-hydroxy-4-methoxypyridine-3-carbonitrile
methyl iodide
2,4-dimethoxypyridine-3-carbonitrile
1,2-dihydro-4-methoxy-1-methyl-2-oxopyridine-3-carboxylic acid
Dimethyl sulfate
2-[3-(Dimethylamino)-1-Methoxy-2-Propenylidene]Malononitrile
4-methoxy-1-methyl-pyridin-2-one
2,4-Dihydroxypyridine
6-chloro-4-methoxy-1-methyl-2-oxopyridine-3-carbonitrile
4-Methoxynicotinonitrile

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Screening approach by ultra-high performance liquid chromatography-tandem mass spectrometry for the blood quantification of thirty-four toxic principles of plant origin. Application to forensic toxicology.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 65-76, (2014)

Plant poisonings have left their mark on history and still cause many deaths, whether intentional or accidental. The means to show toxicological evidence of such poisonings should be implemented with ...

Neutralising antibodies against ricin toxin.

PLoS ONE 6 , e20166, (2011)

The Centers for Disease Control and Prevention have listed the potential bioweapon ricin as a Category B Agent. Ricin is a so-called A/B toxin produced by plants and is one of the deadliest molecules ...

Activity of Ricinus communis (Euphorbiaceae) and ricinine against the leaf-cutting ant Atta sexdens rubropilosa (Hymenoptera: Formicidae) and the symbiotic fungus Leucoagaricus gongylophorus.

Pest Manag. Sci. 60(9) , 933-8, (2004)

The focus of this study was the identification of compounds from plant extracts for use in crop protection. This paper reports on the toxic activity of fractions of leaf extracts of Ricinus communis L...