Flunarizine

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Names

[ CAS No. ]:
52468-60-7

[ Name ]:
Flunarizine

[Synonym ]:
flunarazine
(E)-1-[bis(4-fluorophenyl)methyl]-4-(cinnamyl)piperazine
Sibelium
1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine
1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine
EINECS 257-937-5
(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine
Fluarizine
(e)-piperazin
1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine
1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine
(e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine
MFCD00242731
Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-,(E)

Chemical & Physical Properties

[ Density]:
1.17 g/cm3

[ Boiling Point ]:
511.3ºC at 760 mmHg

[ Molecular Formula ]:
C26H26F2N2

[ Molecular Weight ]:
404.49500

[ Exact Mass ]:
404.20600

[ PSA ]:
6.48000

[ LogP ]:
5.26100

[ Index of Refraction ]:
1.606

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK9188600
CHEMICAL NAME :
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl) -, (E)-
CAS REGISTRY NUMBER :
52468-60-7
LAST UPDATED :
199206
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C26-H26-F2-N2
MOLECULAR WEIGHT :
404.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
4286 ug/kg/30D-I
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
18 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(bis(4-fluorophenyl)methyl)piperazine
  • 3-Phenyl-2-propen-1-ol

DownStream

Related Compounds

  • Flunarizine HCl
  • [2H8]-Flunarizine
  • Hydroxy Flunarizine
  • Flunarizine Impurity 6
  • 4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-4-ol
  • CID 169546462
  • CID 169546463
  • 2-Chloro-3-(methylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
  • (1'-Tert-butoxycarbonylspiro[5,6-dihydropyrrolo[1,2-b]pyrazole-4,3'-azetidine]-2-yl)boronic acid
  • 2-[(1S,2S)-2-[4-(difluoromethyl)phenyl]cyclopropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2-[[(3R)-7-chloro-2,3-dihydrobenzofuran-3-yl]methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • CID 169546476
  • 3-(Difluoromethyl)-2-[trans-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]pyridine
  • 6-[trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]quinoline
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