Flunarizine

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Names

[ CAS No. ]:
52468-60-7

[ Name ]:
Flunarizine

[Synonym ]:
flunarazine
(E)-1-[bis(4-fluorophenyl)methyl]-4-(cinnamyl)piperazine
Sibelium
1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine
1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine
EINECS 257-937-5
(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine
Fluarizine
(e)-piperazin
1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine
1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine
(e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine
MFCD00242731
Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-,(E)

Chemical & Physical Properties

[ Density]:
1.17 g/cm3

[ Boiling Point ]:
511.3ºC at 760 mmHg

[ Molecular Formula ]:
C26H26F2N2

[ Molecular Weight ]:
404.49500

[ Exact Mass ]:
404.20600

[ PSA ]:
6.48000

[ LogP ]:
5.26100

[ Index of Refraction ]:
1.606

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK9188600
CHEMICAL NAME :
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl) -, (E)-
CAS REGISTRY NUMBER :
52468-60-7
LAST UPDATED :
199206
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C26-H26-F2-N2
MOLECULAR WEIGHT :
404.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
4286 ug/kg/30D-I
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
18 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(bis(4-fluorophenyl)methyl)piperazine
  • 3-Phenyl-2-propen-1-ol

DownStream

Related Compounds

  • Flunarizine HCl
  • [2H8]-Flunarizine
  • Hydroxy Flunarizine
  • Flunarizine Impurity 6
  • 3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]formamido}-2,2-dimethylpropanoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide