Flunarizine

Modify Date: 2025-08-25 11:49:45

Flunarizine structure	Common Name	Flunarizine
	CAS Number	52468-60-7	Molecular Weight	404.49500
	Density	1.17 g/cm3	Boiling Point	511.3ºC at 760 mmHg
	Molecular Formula	C₂₆H₂₆F₂N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Flunarizine

Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].

Name	Flunarizine
Synonym	More Synonyms

Description	Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor
In Vitro	Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively[2]. Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells[4]. Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM[4]. Cell Cytotoxicity Assay[4] Cell Line: Chromaffin cells[4] Concentration: 10 and 30 μM Incubation Time: 24 hours Result: Showed a tendency to increase cell death at the concentration of 10 μM, and showed near 100% cell loss at the concentration of 30 μM.
In Vivo	Flunarizine (intraperitoneal injection; 30 mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5]. Animal Model: Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide[5] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg; once Result: Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release. Inhibited the pulmonary inflammation.

Density	1.17 g/cm3
Boiling Point	511.3ºC at 760 mmHg
Molecular Formula	C₂₆H₂₆F₂N₂
Molecular Weight	404.49500
Exact Mass	404.20600
PSA	6.48000
LogP	5.26100
Index of Refraction	1.606
InChIKey	SMANXXCATUTDDT-QPJJXVBHSA-N
SMILES	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CC=Cc3ccccc3)CC2)cc1
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK9188600

CHEMICAL NAME :: Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl) -, (E)-

CAS REGISTRY NUMBER :: 52468-60-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C26-H26-F2-N2

MOLECULAR WEIGHT :: 404.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 4286 ug/kg/30D-I

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 18 mg/kg/90D-I

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

1-(bis(4-fluoro...

CAS#:27469-60-9

3-Phenyl-2-prop...

CAS#:4407-36-7

~68%

Flunarizine

CAS#:52468-60-7

Literature: Banerjee, Debasis; Jagadeesh, Rajenahally V.; Junge, Kathrin; Junge, Henrik; Beller, Matthias ChemSusChem, 2012 , vol. 5, # 10 p. 2039 - 2044

Precursor 2
CAS#:27469-60-9 1-(bis(4-fluoro... CAS#:4407-36-7 3-Phenyl-2-prop...
DownStream 0

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Effect on low-threshold (T-type) Calcium current in primary cultured rat cerebrocorti...
Source: ChEMBL
Target: N/A
External Id: CHEMBL779599

Name: Displacement of [3H]BTX-B from neuronal voltage-gated sodium channel in rat cerebral ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3101695

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel cu...
Source: ChEMBL
Target: Potassium channel subfamily K member 2
External Id: CHEMBL3819955

Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p

Name: qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 green ...
Source: NCGC
Target: N/A
External Id: Ebola screen2_EMI141217_green

Name: qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 ratio ...
Source: NCGC
Target: N/A
External Id: Ebola screen2_EMI141217_ratio

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flunarazine

(E)-1-[bis(4-fluorophenyl)methyl]-4-(cinnamyl)piperazine

Sibelium

1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine

1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine

EINECS 257-937-5

(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine

Fluarizine

(e)-piperazin

1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine

1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine

(e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine

MFCD00242731

Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-,(E)

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Precursor & DownStream

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