berythromycin
Suppliers
Names
[ CAS No. ]:
527-75-3
[ Name ]:
berythromycin
[Synonym ]:
12-Deoxyerythromycin
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione
berythromycinum
berythromycin
beritromicina
berythromycine
(3R,4S,6R,7R,9R,11R,12S,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
erythromycin B
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
berythromycinum [INN_la]
Erythromycin Impurity 2
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
807.6±65.0 °C at 760 mmHg
[ Melting Point ]:
168-170ºC (dec)
[ Molecular Formula ]:
C37H67NO12
[ Molecular Weight ]:
717.927
[ Flash Point ]:
442.2±34.3 °C
[ Exact Mass ]:
717.466309
[ PSA ]:
173.68000
[ LogP ]:
3.12
[ Vapour Pressure ]:
0.0±6.5 mmHg at 25°C
[ Index of Refraction ]:
1.527
[ Storage condition ]:
20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KF4700000
- CHEMICAL NAME :
- Erythromycin, 12-deoxy-
- CAS REGISTRY NUMBER :
- 527-75-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C37-H67-N-O12
- MOLECULAR WEIGHT :
- 718.05
- WISWESSER LINE NOTATION :
- T-14-VO GVTJ C2 D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,58,1980
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Rapid Commun. Mass Spectrom. 21(2) , 237-46, (2007)
A rapid and simple sample preparation procedure for determining residues of antibiotics of the class of macrolides and lincomycin in whole milk and yoghurt by liquid chromatography/tandem mass spectro...
J. Med. Chem. 43(3) , 467-74, (2000)
One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clari...
Angew. Chem. Int. Ed. Engl. 42(28) , 3278-81, (2003)