Chamazulene

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Names

[ CAS No. ]:
529-05-5

[ Name ]:
Chamazulene

[Synonym ]:
7-Ethyl-1,4-dimethylazulene
Azulene, 7-ethyl-1,4-dimethyl-
Chamazulene
7-Ethyl-1,4-dimethylazulene Chamazulen Dimethulene

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
299.1±20.0 °C at 760 mmHg

[ Melting Point ]:
<25℃

[ Molecular Formula ]:
C14H16

[ Molecular Weight ]:
184.277

[ Flash Point ]:
137.4±12.5 °C

[ Exact Mass ]:
184.125198

[ LogP ]:
5.36

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CO4780000
CHEMICAL NAME :
Azulene, 1,4-dimethyl-7-ethyl-
CAS REGISTRY NUMBER :
529-05-5
BEILSTEIN REFERENCE NO. :
1306577
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H16
MOLECULAR WEIGHT :
184.30
WISWESSER LINE NOTATION :
L57J B1 F1 I2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
REFERENCE :
RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967

Safety Information

[ Hazard Statements ]:
H413

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2902909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methylboronic acid
  • Isodehydrocostus lactone
  • Azuleno[4,5-b]furan-2(3H)-one,3a,4,6a,7,8,9,9a,9b-octahydro-6-methyl-3,9-bis(methylene)-, (3aS,6aR,9aR,9bS)-
  • Oxireno[1,2]azuleno[4,5-b]furan-2(3H)-one, decahydro-6,8-dihydroxy-6,8-dimethyl-3-methylene-, (3aS,6R,6aS,6bR,7aR,8S,8aS,8bS)
  • artenolide
  • 6-Oxo-2.8-dimethyl-bicyclo[5.3.0]decan
  • 1.4-Dimethyl-7-aethyl-carbomethoxy-bicyclo-[5:3:0]-decanon-(8)

DownStream

Customs

[ HS Code ]: 2902909090

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation.

Planta Med. 60(5) , 410-3, (1994)

Matricine and its transformation product chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile ...

[Pharmacologic studies on chamomile compounds. VI. Studies on the antiphlogistic effect of chamazulene and matricine].

Planta Med. 49(2) , 67-73, (1983)


More Articles

Related Compounds

  • chamazulene
  • Chamazulene, 3-acetyl- (5CI)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 4,6-Pyrimidinediamine, N4-[2-methyl-3-(methylthio)propyl]-N6,5-dipropyl-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide